EKB57498.1 protein (Bergeyella zoohelcum) - STRING interaction network

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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gene co-occurrence

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[Homology]

Score

EKB57498.1

Hypothetical protein. (493 aa)

Predicted Functional Partners:

EKB57500.1

0.990

EKB57499.1

0.957

EKB59592.1

0.944

EKB59318.1

0.944

EKB59338.1

0.944

EKB57269.1

0.944

sbcD

0.942

EKB56549.1

0.938

gmk

0.919

rpsC

0.916

Your Current Organism:

Bergeyella zoohelcum

NCBI taxonomy Id: 883096
Other names: B. zoohelcum ATCC 43767, Bergeyella zoohelcum ATCC 43767

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EKB56549.1	EKB57269.1	HMPREF9699_01278	HMPREF9699_01120	Hypothetical protein.	Hypothetical protein.	0.846
EKB56549.1	EKB57498.1	HMPREF9699_01278	HMPREF9699_00984	Hypothetical protein.	Hypothetical protein.	0.938
EKB56549.1	EKB59318.1	HMPREF9699_01278	HMPREF9699_00254	Hypothetical protein.	Hypothetical protein.	0.846
EKB56549.1	EKB59338.1	HMPREF9699_01278	HMPREF9699_00274	Hypothetical protein.	Hypothetical protein.	0.846
EKB56549.1	EKB59592.1	HMPREF9699_01278	HMPREF9699_00161	Hypothetical protein.	Hypothetical protein.	0.846
EKB56549.1	rpsC	HMPREF9699_01278	HMPREF9699_00027	Hypothetical protein.	30S ribosomal protein S3; Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation; Belongs to the universal ribosomal protein uS3 family.	0.859
EKB57269.1	EKB56549.1	HMPREF9699_01120	HMPREF9699_01278	Hypothetical protein.	Hypothetical protein.	0.846
EKB57269.1	EKB57498.1	HMPREF9699_01120	HMPREF9699_00984	Hypothetical protein.	Hypothetical protein.	0.944
EKB57269.1	gmk	HMPREF9699_01120	HMPREF9699_02080	Hypothetical protein.	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	0.432
EKB57498.1	EKB56549.1	HMPREF9699_00984	HMPREF9699_01278	Hypothetical protein.	Hypothetical protein.	0.938
EKB57498.1	EKB57269.1	HMPREF9699_00984	HMPREF9699_01120	Hypothetical protein.	Hypothetical protein.	0.944
EKB57498.1	EKB57499.1	HMPREF9699_00984	HMPREF9699_00985	Hypothetical protein.	Hypothetical protein.	0.957
EKB57498.1	EKB57500.1	HMPREF9699_00984	HMPREF9699_00986	Hypothetical protein.	Hypothetical protein.	0.990
EKB57498.1	EKB59318.1	HMPREF9699_00984	HMPREF9699_00254	Hypothetical protein.	Hypothetical protein.	0.944
EKB57498.1	EKB59338.1	HMPREF9699_00984	HMPREF9699_00274	Hypothetical protein.	Hypothetical protein.	0.944
EKB57498.1	EKB59592.1	HMPREF9699_00984	HMPREF9699_00161	Hypothetical protein.	Hypothetical protein.	0.944
EKB57498.1	gmk	HMPREF9699_00984	HMPREF9699_02080	Hypothetical protein.	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	0.919
EKB57498.1	rpsC	HMPREF9699_00984	HMPREF9699_00027	Hypothetical protein.	30S ribosomal protein S3; Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation; Belongs to the universal ribosomal protein uS3 family.	0.916
EKB57498.1	sbcD	HMPREF9699_00984	HMPREF9699_01888	Hypothetical protein.	Exonuclease SbcCD, D subunit; SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity; Belongs to the SbcD family.	0.942
EKB57499.1	EKB57498.1	HMPREF9699_00985	HMPREF9699_00984	Hypothetical protein.	Hypothetical protein.	0.957

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Network Stats

number of nodes:

6

number of edges:

11

average node degree:

3.67

avg. local clustering coefficient:

0.839

expected number of edges:

5

PPI enrichment p-value:

0.0141

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006304

DNA modification

6 of 19

2.05

4.48

1.28e-09

GO:0006306

DNA methylation

5 of 12

2.17

4.09

4.77e-08

GO:0009307

DNA restriction-modification system

3 of 10

2.03

2.04

0.00038

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009008

DNA-methyltransferase activity

3 of 9

2.08

2.02

0.00047

GO:0008168

Methyltransferase activity

5 of 53

1.53

1.9

3.76e-05

GO:0008170

N-methyltransferase activity

3 of 12

1.95

1.85

0.00073

GO:0008757

S-adenosylmethionine-dependent methyltransferase activity

3 of 29

1.57

1.25

0.0045

GO:0009007

Site-specific DNA-methyltransferase (adenine-specific) activity

2 of 6

2.08

1.22

0.0121

(more ...)

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:37701958

(2023) Exploring the links between gut microbiome changes and irritable bowel syndrome in Han populations in the Tibetan Plateau.

2 of 2

2.55

1.8

0.0019

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:4019

Adenine modification methylase, M.EcoRV-type, and DNA methylase N-4/N-6

5 of 5

2.55

5.36

1.94e-09

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03430

Mismatch repair

3 of 30

1.55

1.17

0.0065

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0489

Methyltransferase

5 of 42

1.63

2.33

4.33e-06

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02086

D12 class N6 adenine-specific DNA methyltransferase

2 of 2

2.55

1.26

0.0127

PF01555

DNA methylase

2 of 3

2.38

1.25

0.0127

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR029063

S-adenosyl-L-methionine-dependent methyltransferase superfamily

5 of 28

1.81

2.7

3.27e-06

IPR002941

DNA methylase N-4/N-6

3 of 4

2.43

2.39

0.00019

IPR002052

DNA methylase, N-6 adenine-specific, conserved site

3 of 8

2.13

1.99

0.00059

IPR023095

Adenine-specific methyltransferase, domain 2

2 of 2

2.55

1.37

0.0087

IPR012327

D12 class N6 adenine-specific DNA methyltransferase

2 of 2

2.55

1.37

0.0087

(more ...)

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