| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EHO84695.1 | EHO85722.1 | HMPREF0380_01096 | HMPREF0380_00846 | Phosphoribosylformylglycinamidine synthase. | GMP synthase 2. | 0.997 |
| EHO84695.1 | EHO86240.1 | HMPREF0380_01096 | HMPREF0380_00532 | Phosphoribosylformylglycinamidine synthase. | Hypothetical protein; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | 0.903 |
| EHO84695.1 | guaA | HMPREF0380_01096 | HMPREF0380_01571 | Phosphoribosylformylglycinamidine synthase. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.997 |
| EHO84695.1 | murD | HMPREF0380_01096 | HMPREF0380_00581 | Phosphoribosylformylglycinamidine synthase. | UDP-N-acetylmuramoylalanine-D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. | 0.855 |
| EHO84695.1 | murI | HMPREF0380_01096 | HMPREF0380_01040 | Phosphoribosylformylglycinamidine synthase. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.858 |
| EHO85722.1 | EHO84695.1 | HMPREF0380_00846 | HMPREF0380_01096 | GMP synthase 2. | Phosphoribosylformylglycinamidine synthase. | 0.997 |
| EHO85722.1 | EHO86356.1 | HMPREF0380_00846 | HMPREF0380_00648 | GMP synthase 2. | Ham1 family protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.930 |
| EHO85722.1 | guaA | HMPREF0380_00846 | HMPREF0380_01571 | GMP synthase 2. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.848 |
| EHO85722.1 | murC | HMPREF0380_00846 | HMPREF0380_01736 | GMP synthase 2. | UDP-N-acetylmuramate-alanine ligase; Cell wall formation; Belongs to the MurCDEF family. | 0.426 |
| EHO85722.1 | murI | HMPREF0380_00846 | HMPREF0380_01040 | GMP synthase 2. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.848 |
| EHO86240.1 | EHO84695.1 | HMPREF0380_00532 | HMPREF0380_01096 | Hypothetical protein; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | Phosphoribosylformylglycinamidine synthase. | 0.903 |
| EHO86240.1 | murI | HMPREF0380_00532 | HMPREF0380_01040 | Hypothetical protein; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.850 |
| EHO86356.1 | EHO85722.1 | HMPREF0380_00648 | HMPREF0380_00846 | Ham1 family protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | GMP synthase 2. | 0.930 |
| EHO86356.1 | guaA | HMPREF0380_00648 | HMPREF0380_01571 | Ham1 family protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.933 |
| EHO86356.1 | murD | HMPREF0380_00648 | HMPREF0380_00581 | Ham1 family protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | UDP-N-acetylmuramoylalanine-D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. | 0.424 |
| EHO86356.1 | murI | HMPREF0380_00648 | HMPREF0380_01040 | Ham1 family protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.935 |
| guaA | EHO84695.1 | HMPREF0380_01571 | HMPREF0380_01096 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Phosphoribosylformylglycinamidine synthase. | 0.997 |
| guaA | EHO85722.1 | HMPREF0380_01571 | HMPREF0380_00846 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | GMP synthase 2. | 0.848 |
| guaA | EHO86356.1 | HMPREF0380_01571 | HMPREF0380_00648 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Ham1 family protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.933 |
| guaA | murC | HMPREF0380_01571 | HMPREF0380_01736 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | UDP-N-acetylmuramate-alanine ligase; Cell wall formation; Belongs to the MurCDEF family. | 0.426 |