node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EHR32088.1 | EHR34076.1 | HMPREF9709_01702 | HMPREF9709_01012 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | ATP-dependent DNA helicase PcrA. | 0.943 |
EHR32088.1 | EHR34834.1 | HMPREF9709_01702 | HMPREF9709_00576 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | Hypothetical protein. | 0.929 |
EHR32088.1 | EHR35718.1 | HMPREF9709_01702 | HMPREF9709_00272 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | Hypothetical protein; ATP-dependent DNA helicase; Belongs to the helicase family. UvrD subfamily. | 0.943 |
EHR32088.1 | EHR35775.1 | HMPREF9709_01702 | HMPREF9709_00221 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | Hypothetical protein. | 0.827 |
EHR32088.1 | dnaG | HMPREF9709_01702 | HMPREF9709_01241 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. | 0.561 |
EHR32088.1 | recA | HMPREF9709_01702 | HMPREF9709_00756 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | Protein RecA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.974 |
EHR32088.1 | topA | HMPREF9709_01702 | HMPREF9709_00866 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.925 |
EHR34076.1 | EHR32088.1 | HMPREF9709_01012 | HMPREF9709_01702 | ATP-dependent DNA helicase PcrA. | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.943 |
EHR34076.1 | EHR34668.1 | HMPREF9709_01012 | HMPREF9709_00638 | ATP-dependent DNA helicase PcrA. | Helicase-exonuclease AddAB, AddA subunit; ATP-dependent DNA helicase. | 0.750 |
EHR34076.1 | EHR34834.1 | HMPREF9709_01012 | HMPREF9709_00576 | ATP-dependent DNA helicase PcrA. | Hypothetical protein. | 0.972 |
EHR34076.1 | EHR35718.1 | HMPREF9709_01012 | HMPREF9709_00272 | ATP-dependent DNA helicase PcrA. | Hypothetical protein; ATP-dependent DNA helicase; Belongs to the helicase family. UvrD subfamily. | 0.933 |
EHR34076.1 | EHR35775.1 | HMPREF9709_01012 | HMPREF9709_00221 | ATP-dependent DNA helicase PcrA. | Hypothetical protein. | 0.579 |
EHR34076.1 | dnaG | HMPREF9709_01012 | HMPREF9709_01241 | ATP-dependent DNA helicase PcrA. | DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. | 0.647 |
EHR34076.1 | recA | HMPREF9709_01012 | HMPREF9709_00756 | ATP-dependent DNA helicase PcrA. | Protein RecA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.936 |
EHR34076.1 | topA | HMPREF9709_01012 | HMPREF9709_00866 | ATP-dependent DNA helicase PcrA. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.857 |
EHR34648.1 | EHR35473.1 | HMPREF9709_00618 | HMPREF9709_00425 | Hypothetical protein. | Hypothetical protein. | 0.515 |
EHR34648.1 | EHR35775.1 | HMPREF9709_00618 | HMPREF9709_00221 | Hypothetical protein. | Hypothetical protein. | 0.671 |
EHR34668.1 | EHR34076.1 | HMPREF9709_00638 | HMPREF9709_01012 | Helicase-exonuclease AddAB, AddA subunit; ATP-dependent DNA helicase. | ATP-dependent DNA helicase PcrA. | 0.750 |
EHR34668.1 | EHR34834.1 | HMPREF9709_00638 | HMPREF9709_00576 | Helicase-exonuclease AddAB, AddA subunit; ATP-dependent DNA helicase. | Hypothetical protein. | 0.691 |
EHR34668.1 | EHR35718.1 | HMPREF9709_00638 | HMPREF9709_00272 | Helicase-exonuclease AddAB, AddA subunit; ATP-dependent DNA helicase. | Hypothetical protein; ATP-dependent DNA helicase; Belongs to the helicase family. UvrD subfamily. | 0.963 |