node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EHR33536.1 | EHR33537.1 | HMPREF9709_01135 | HMPREF9709_01136 | L-serine dehydratase, iron-sulfur-dependent, alpha subunit. | L-serine dehydratase, iron-sulfur-dependent, beta subunit. | 0.999 |
EHR33536.1 | glyA | HMPREF9709_01135 | HMPREF9709_00796 | L-serine dehydratase, iron-sulfur-dependent, alpha subunit. | Hypothetical protein; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.984 |
EHR33537.1 | EHR33536.1 | HMPREF9709_01136 | HMPREF9709_01135 | L-serine dehydratase, iron-sulfur-dependent, beta subunit. | L-serine dehydratase, iron-sulfur-dependent, alpha subunit. | 0.999 |
EHR33537.1 | glyA | HMPREF9709_01136 | HMPREF9709_00796 | L-serine dehydratase, iron-sulfur-dependent, beta subunit. | Hypothetical protein; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.984 |
EHR34117.1 | EHR35067.1 | HMPREF9709_01053 | HMPREF9709_00493 | Hypothetical protein; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Hypothetical protein. | 0.754 |
EHR34117.1 | EHR36426.1 | HMPREF9709_01053 | HMPREF9709_00013 | Hypothetical protein; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Dihydrolipoyl dehydrogenase. | 0.617 |
EHR34117.1 | fhs | HMPREF9709_01053 | HMPREF9709_00523 | Hypothetical protein; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Hypothetical protein; Belongs to the formate--tetrahydrofolate ligase family. | 0.976 |
EHR34117.1 | fmt | HMPREF9709_01053 | HMPREF9709_00850 | Hypothetical protein; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.976 |
EHR34117.1 | glyA | HMPREF9709_01053 | HMPREF9709_00796 | Hypothetical protein; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Hypothetical protein; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.976 |
EHR34117.1 | purH | HMPREF9709_01053 | HMPREF9709_00521 | Hypothetical protein; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. | 0.973 |
EHR34117.1 | purN | HMPREF9709_01053 | HMPREF9709_00520 | Hypothetical protein; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.973 |
EHR35042.1 | EHR35067.1 | HMPREF9709_00517 | HMPREF9709_00493 | Phosphoribosylformylglycinamidine synthase. | Hypothetical protein. | 0.859 |
EHR35042.1 | EHR36426.1 | HMPREF9709_00517 | HMPREF9709_00013 | Phosphoribosylformylglycinamidine synthase. | Dihydrolipoyl dehydrogenase. | 0.958 |
EHR35042.1 | fhs | HMPREF9709_00517 | HMPREF9709_00523 | Phosphoribosylformylglycinamidine synthase. | Hypothetical protein; Belongs to the formate--tetrahydrofolate ligase family. | 0.983 |
EHR35042.1 | fmt | HMPREF9709_00517 | HMPREF9709_00850 | Phosphoribosylformylglycinamidine synthase. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.984 |
EHR35042.1 | glyA | HMPREF9709_00517 | HMPREF9709_00796 | Phosphoribosylformylglycinamidine synthase. | Hypothetical protein; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.980 |
EHR35042.1 | purH | HMPREF9709_00517 | HMPREF9709_00521 | Phosphoribosylformylglycinamidine synthase. | Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. | 0.999 |
EHR35042.1 | purN | HMPREF9709_00517 | HMPREF9709_00520 | Phosphoribosylformylglycinamidine synthase. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.999 |
EHR35067.1 | EHR34117.1 | HMPREF9709_00493 | HMPREF9709_01053 | Hypothetical protein. | Hypothetical protein; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.754 |
EHR35067.1 | EHR35042.1 | HMPREF9709_00493 | HMPREF9709_00517 | Hypothetical protein. | Phosphoribosylformylglycinamidine synthase. | 0.859 |