EHR34031.1 protein (Helcococcus kunzii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

EHR34031.1

Hypothetical protein. (223 aa)

Predicted Functional Partners:

EHR35053.1

0.999

EHR34030.1

0.999

metN

0.998

EHR34032.1

0.998

EHR34033.1

0.565

EHR31916.1

0.508

EHR33532.1

0.479

EHR33534.1

0.479

EHR36058.1

0.452

EHR35858.1

0.452

Your Current Organism:

Helcococcus kunzii

NCBI taxonomy Id: 883114
Other names: H. kunzii ATCC 51366, Helcococcus kunzii ATCC 51366

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EHR31916.1	EHR33532.1	HMPREF9709_01729	HMPREF9709_01131	Hypothetical protein.	Hypothetical protein.	0.863
EHR31916.1	EHR33534.1	HMPREF9709_01729	HMPREF9709_01133	Hypothetical protein.	Hypothetical protein.	0.859
EHR31916.1	EHR34030.1	HMPREF9709_01729	HMPREF9709_00966	Hypothetical protein.	YaeC family lipoprotein.	0.551
EHR31916.1	EHR34031.1	HMPREF9709_01729	HMPREF9709_00967	Hypothetical protein.	Hypothetical protein.	0.508
EHR31916.1	EHR35053.1	HMPREF9709_01729	HMPREF9709_00479	Hypothetical protein.	YaeC family lipoprotein; Belongs to the nlpA lipoprotein family.	0.551
EHR33532.1	EHR31916.1	HMPREF9709_01131	HMPREF9709_01729	Hypothetical protein.	Hypothetical protein.	0.863
EHR33532.1	EHR33534.1	HMPREF9709_01131	HMPREF9709_01133	Hypothetical protein.	Hypothetical protein.	0.975
EHR33532.1	EHR34030.1	HMPREF9709_01131	HMPREF9709_00966	Hypothetical protein.	YaeC family lipoprotein.	0.546
EHR33532.1	EHR34031.1	HMPREF9709_01131	HMPREF9709_00967	Hypothetical protein.	Hypothetical protein.	0.479
EHR33532.1	EHR35053.1	HMPREF9709_01131	HMPREF9709_00479	Hypothetical protein.	YaeC family lipoprotein; Belongs to the nlpA lipoprotein family.	0.546
EHR33534.1	EHR31916.1	HMPREF9709_01133	HMPREF9709_01729	Hypothetical protein.	Hypothetical protein.	0.859
EHR33534.1	EHR33532.1	HMPREF9709_01133	HMPREF9709_01131	Hypothetical protein.	Hypothetical protein.	0.975
EHR33534.1	EHR34030.1	HMPREF9709_01133	HMPREF9709_00966	Hypothetical protein.	YaeC family lipoprotein.	0.546
EHR33534.1	EHR34031.1	HMPREF9709_01133	HMPREF9709_00967	Hypothetical protein.	Hypothetical protein.	0.479
EHR33534.1	EHR35053.1	HMPREF9709_01133	HMPREF9709_00479	Hypothetical protein.	YaeC family lipoprotein; Belongs to the nlpA lipoprotein family.	0.546
EHR34030.1	EHR31916.1	HMPREF9709_00966	HMPREF9709_01729	YaeC family lipoprotein.	Hypothetical protein.	0.551
EHR34030.1	EHR33532.1	HMPREF9709_00966	HMPREF9709_01131	YaeC family lipoprotein.	Hypothetical protein.	0.546
EHR34030.1	EHR33534.1	HMPREF9709_00966	HMPREF9709_01133	YaeC family lipoprotein.	Hypothetical protein.	0.546
EHR34030.1	EHR34031.1	HMPREF9709_00966	HMPREF9709_00967	YaeC family lipoprotein.	Hypothetical protein.	0.999
EHR34030.1	EHR34032.1	HMPREF9709_00966	HMPREF9709_00968	YaeC family lipoprotein.	Hypothetical protein; Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Methionine importer (TC 3.A.1.24) family.	0.998

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

53

average node degree:

9.64

avg. local clustering coefficient:

0.968

expected number of edges:

12

PPI enrichment p-value:

< 1.0e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006418

tRNA aminoacylation for protein translation

10 of 48

2.46

9.16

7.24e-21

GO:0006428

isoleucyl-tRNA aminoacylation

3 of 4

3.02

3.37

6.93e-07

GO:0006433

prolyl-tRNA aminoacylation

2 of 2

3.14

2.06

0.00019

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004812

aminoacyl-tRNA ligase activity

9 of 47

2.43

8.0

3.99e-18

GO:0002161

aminoacyl-tRNA editing activity

4 of 11

2.71

3.97

3.48e-08

GO:0004822

isoleucine-tRNA ligase activity

3 of 4

3.02

3.19

1.50e-06

GO:0004827

proline-tRNA ligase activity

2 of 2

3.14

2.12

0.00015

GO:0005524

ATP binding

9 of 1375

0.96

1.04

2.49e-06

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:8312

Selenoamino acid metabolism, and tRNA-binding domain

11 of 16

2.98

14.25

1.05e-28

CL:8314

Cytosolic tRNA aminoacylation

9 of 10

3.1

12.12

9.77e-24

CL:8319

tRNA synthetases class I (E and Q), anti-codon binding domain, and prolyl-tRNA aminoacylation

5 of 5

3.14

6.29

2.64e-12

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00970

Aminoacyl-tRNA biosynthesis

10 of 61

2.36

8.83

3.40e-21

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-379716

Cytosolic tRNA aminoacylation

9 of 19

2.82

10.58

1.18e-21

MAP-379724

tRNA Aminoacylation

10 of 43

2.51

9.69

8.68e-22

MAP-2408522

Selenoamino acid metabolism

8 of 16

2.84

9.44

4.29e-19

MAP-72766

Translation

10 of 210

1.82

4.84

6.55e-16

MAP-71291

Metabolism of amino acids and derivatives

8 of 197

1.75

3.68

2.28e-11

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0017101

aminoacyl-tRNA synthetase multienzyme complex

4 of 10

2.75

3.71

1.22e-07

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0030

Aminoacyl-tRNA synthetase

4 of 20

2.45

3.36

3.38e-07

KW-0648

Protein biosynthesis

4 of 53

2.02

2.57

4.14e-06

KW-0820

tRNA-binding

2 of 10

2.45

1.5

0.0017

KW-0067

ATP-binding

4 of 635

0.94

0.53

0.0349

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF09334

tRNA synthetases class I (M)

3 of 7

2.78

2.4

3.97e-05

PF03950

tRNA synthetases class I (E and Q), anti-codon binding domain

2 of 2

3.14

1.54

0.0017

PF01588

Putative tRNA binding domain

2 of 4

2.84

1.41

0.0028

PF03129

Anticodon binding domain

2 of 7

2.6

1.26

0.0051

PF08264

Anticodon-binding domain of tRNA ligase

2 of 9

2.49

1.2

0.0062

(more ...)

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR014729

Rossmann-like alpha/beta/alpha sandwich fold

6 of 60

2.14

3.8

7.64e-09

IPR001412

Aminoacyl-tRNA synthetase, class I, conserved site

4 of 15

2.57

3.2

9.25e-07

IPR023586

Isoleucine-tRNA ligase, type 2

3 of 3

3.14

2.87

6.14e-06

IPR002301

Isoleucine-tRNA ligase

3 of 4

3.02

2.8

8.05e-06

IPR009008

Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain

3 of 9

2.67

2.38

4.04e-05

(more ...)

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (30%) [HD]

Permalink

Credits

Access

Info

About

STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.

Network

Neighborhood

Experiments

Fusion

Databases

Cooccurrence

Textmining

Coexpression

© STRING Consortium 2025

Credits

Access

Info

About