ecfA-2 protein (Helcococcus kunzii) - STRING interaction network

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second shell of interactors

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Edges:

Edges represent protein-protein associations

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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co-expression

protein homology

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ecfA-2

Hypothetical protein; ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. (268 aa)

Predicted Functional Partners:

EHR34153.1

0.999

ecfA

0.993

EHR34733.1

0.981

EHR31706.1

0.977

EHR31961.1

0.974

EHR33998.1

0.954

EHR34442.1

0.945

EHR35858.1

0.938

EHR35700.1

0.935

EHR34654.1

0.933

Your Current Organism:

Helcococcus kunzii

NCBI taxonomy Id: 883114
Other names: H. kunzii ATCC 51366, Helcococcus kunzii ATCC 51366

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EHR31706.1	EHR33998.1	HMPREF9709_01824	HMPREF9709_00934	Hypothetical protein.	Hypothetical protein.	0.932
EHR31706.1	EHR34733.1	HMPREF9709_01824	HMPREF9709_00606	Hypothetical protein.	Hypothetical protein.	0.969
EHR31706.1	EHR35858.1	HMPREF9709_01824	HMPREF9709_00217	Hypothetical protein.	Hypothetical protein.	0.468
EHR31706.1	ecfA	HMPREF9709_01824	HMPREF9709_01090	Hypothetical protein.	Hypothetical protein; ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates.	0.977
EHR31706.1	ecfA-2	HMPREF9709_01824	HMPREF9709_01091	Hypothetical protein.	Hypothetical protein; ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates.	0.977
EHR31961.1	EHR33998.1	HMPREF9709_01774	HMPREF9709_00934	Hypothetical protein.	Hypothetical protein.	0.932
EHR31961.1	EHR34733.1	HMPREF9709_01774	HMPREF9709_00606	Hypothetical protein.	Hypothetical protein.	0.969
EHR31961.1	EHR35858.1	HMPREF9709_01774	HMPREF9709_00217	Hypothetical protein.	Hypothetical protein.	0.468
EHR31961.1	ecfA	HMPREF9709_01774	HMPREF9709_01090	Hypothetical protein.	Hypothetical protein; ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates.	0.972
EHR31961.1	ecfA-2	HMPREF9709_01774	HMPREF9709_01091	Hypothetical protein.	Hypothetical protein; ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates.	0.974
EHR33998.1	EHR31706.1	HMPREF9709_00934	HMPREF9709_01824	Hypothetical protein.	Hypothetical protein.	0.932
EHR33998.1	EHR31961.1	HMPREF9709_00934	HMPREF9709_01774	Hypothetical protein.	Hypothetical protein.	0.932
EHR33998.1	EHR34153.1	HMPREF9709_00934	HMPREF9709_01089	Hypothetical protein.	Hypothetical protein.	0.940
EHR33998.1	EHR34733.1	HMPREF9709_00934	HMPREF9709_00606	Hypothetical protein.	Hypothetical protein.	0.429
EHR33998.1	ecfA	HMPREF9709_00934	HMPREF9709_01090	Hypothetical protein.	Hypothetical protein; ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates.	0.967
EHR33998.1	ecfA-2	HMPREF9709_00934	HMPREF9709_01091	Hypothetical protein.	Hypothetical protein; ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates.	0.954
EHR34153.1	EHR33998.1	HMPREF9709_01089	HMPREF9709_00934	Hypothetical protein.	Hypothetical protein.	0.940
EHR34153.1	EHR34733.1	HMPREF9709_01089	HMPREF9709_00606	Hypothetical protein.	Hypothetical protein.	0.977
EHR34153.1	EHR35858.1	HMPREF9709_01089	HMPREF9709_00217	Hypothetical protein.	Hypothetical protein.	0.468
EHR34153.1	ecfA	HMPREF9709_01089	HMPREF9709_01090	Hypothetical protein.	Hypothetical protein; ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates.	0.999

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Network Stats

number of nodes:

11

number of edges:

29

average node degree:

5.27

avg. local clustering coefficient:

0.911

expected number of edges:

11

PPI enrichment p-value:

2.24e-06

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0007035

Vacuolar acidification

4 of 11

2.23

2.14

7.25e-05

GO:0070072

Vacuolar proton-transporting V-type ATPase complex assembly

2 of 5

2.27

0.88

0.0243

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0046961

Proton-transporting ATPase activity, rotational mechanism

4 of 15

2.1

2.0

0.00011

GO:0015075

Ion transmembrane transporter activity

5 of 184

1.1

0.79

0.0061

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016471

Vacuolar proton-transporting V-type ATPase complex

4 of 14

2.13

2.23

3.64e-05

GO:0000220

Vacuolar proton-transporting V-type ATPase, V0 domain

3 of 6

2.37

1.94

0.00022

GO:0000329

Fungal-type vacuole membrane

5 of 120

1.29

1.17

0.00057

GO:0098588

Bounding membrane of organelle

6 of 450

0.79

0.54

0.0104

GO:0031090

Organelle membrane

9 of 997

0.63

0.49

0.0018

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:26791325

(2016) Predicting chemotherapeutic drug combinations through gene network profiling.

5 of 27

1.94

2.06

5.26e-05

PMID:36422040

(2022) Subunit C of V-ATPase-VmaC Is Required for Hyphal Growth and Conidiation in A. fumigatus by Affecting Vacuolar Calcium Homeostasis and Cell Wall Integration.

4 of 15

2.1

1.75

0.00038

PMID:24708151

(2014) A functional screen for copper homeostasis genes identifies a pharmacologically tractable cellular system.

4 of 18

2.02

1.68

0.00047

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2344

Vacuolar proton-transporting V-type ATPase complex

4 of 13

2.16

2.29

2.95e-05

CL:7052

Mixed, incl. Vacuolar proton-transporting V-type ATPase complex assembly, and Exopolyphosphatase activity

4 of 19

1.99

2.08

5.45e-05

CL:7055

Mixed, incl. Glycine transport, and Cactus-binding C-terminus of cactin protein

3 of 6

2.37

2.0

0.00017

CL:2348

Insulin receptor recycling

3 of 8

2.24

1.91

0.00022

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

spo04145

Phagosome

4 of 33

1.75

1.85

7.82e-05

spo00190

Oxidative phosphorylation

4 of 65

1.46

1.34

0.00049

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

SPO-917977

Transferrin endocytosis and recycling

4 of 13

2.16

2.38

1.85e-05

SPO-77387

Insulin receptor recycling

4 of 13

2.16

2.38

1.85e-05

SPO-1222556

ROS and RNS production in phagocytes

4 of 14

2.13

2.37

1.85e-05

SPO-9639288

Amino acids regulate mTORC1

4 of 20

1.97

2.27

1.85e-05

SPO-168249

Innate Immune System

5 of 191

1.09

0.89

0.0017

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0016471

Vacuolar proton-transporting V-type ATPase complex

4 of 14

2.13

2.26

3.15e-05

GOCC:0000220

Vacuolar proton-transporting V-type ATPase, V0 domain

3 of 6

2.37

2.04

0.00014

GOCC:0005774

Vacuolar membrane

5 of 133

1.24

1.12

0.00060

GOCC:0031090

Organelle membrane

9 of 616

0.83

0.77

7.33e-05

GOCC:0098588

Bounding membrane of organelle

6 of 313

0.95

0.77

0.0016

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0375

Hydrogen ion transport

4 of 33

1.75

1.68

0.00023

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