node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EHR32074.1 | EHR32075.1 | HMPREF9709_01688 | HMPREF9709_01689 | Ribonucleoside-diphosphate reductase, alpha chain. | Hypothetical protein. | 0.999 |
EHR32074.1 | EHR34730.1 | HMPREF9709_01688 | HMPREF9709_00603 | Ribonucleoside-diphosphate reductase, alpha chain. | Anaerobic ribonucleoside-triphosphate reductase. | 0.708 |
EHR32074.1 | EHR35706.1 | HMPREF9709_01688 | HMPREF9709_00397 | Ribonucleoside-diphosphate reductase, alpha chain. | Pyruvate kinase; Belongs to the pyruvate kinase family. | 0.975 |
EHR32074.1 | dut | HMPREF9709_01688 | HMPREF9709_01237 | Ribonucleoside-diphosphate reductase, alpha chain. | dUTP diphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.889 |
EHR32074.1 | tdk | HMPREF9709_01688 | HMPREF9709_00416 | Ribonucleoside-diphosphate reductase, alpha chain. | Hypothetical protein. | 0.457 |
EHR32074.1 | thyA | HMPREF9709_01688 | HMPREF9709_01052 | Ribonucleoside-diphosphate reductase, alpha chain. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.847 |
EHR32075.1 | EHR32074.1 | HMPREF9709_01689 | HMPREF9709_01688 | Hypothetical protein. | Ribonucleoside-diphosphate reductase, alpha chain. | 0.999 |
EHR32075.1 | EHR34730.1 | HMPREF9709_01689 | HMPREF9709_00603 | Hypothetical protein. | Anaerobic ribonucleoside-triphosphate reductase. | 0.781 |
EHR32075.1 | EHR35706.1 | HMPREF9709_01689 | HMPREF9709_00397 | Hypothetical protein. | Pyruvate kinase; Belongs to the pyruvate kinase family. | 0.981 |
EHR32075.1 | dut | HMPREF9709_01689 | HMPREF9709_01237 | Hypothetical protein. | dUTP diphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.964 |
EHR32075.1 | tdk | HMPREF9709_01689 | HMPREF9709_00416 | Hypothetical protein. | Hypothetical protein. | 0.481 |
EHR32075.1 | thyA | HMPREF9709_01689 | HMPREF9709_01052 | Hypothetical protein. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.578 |
EHR33917.1 | EHR35637.1 | HMPREF9709_00853 | HMPREF9709_00328 | Phosphopantothenoylcysteine decarboxylase/phosphopantothenate-cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | Hypothetical protein. | 0.649 |
EHR33917.1 | dut | HMPREF9709_00853 | HMPREF9709_01237 | Phosphopantothenoylcysteine decarboxylase/phosphopantothenate-cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | dUTP diphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.985 |
EHR33917.1 | thyA | HMPREF9709_00853 | HMPREF9709_01052 | Phosphopantothenoylcysteine decarboxylase/phosphopantothenate-cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.668 |
EHR34071.1 | EHR35706.1 | HMPREF9709_01007 | HMPREF9709_00397 | rdgB/HAM1 family non-canonical purine NTP pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Pyruvate kinase; Belongs to the pyruvate kinase family. | 0.765 |
EHR34071.1 | EHR35852.1 | HMPREF9709_01007 | HMPREF9709_00211 | rdgB/HAM1 family non-canonical purine NTP pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Hypothetical protein; Belongs to the peptidase S8 family. | 0.887 |
EHR34071.1 | dut | HMPREF9709_01007 | HMPREF9709_01237 | rdgB/HAM1 family non-canonical purine NTP pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | dUTP diphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.851 |
EHR34071.1 | thyA | HMPREF9709_01007 | HMPREF9709_01052 | rdgB/HAM1 family non-canonical purine NTP pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.713 |
EHR34730.1 | EHR32074.1 | HMPREF9709_00603 | HMPREF9709_01688 | Anaerobic ribonucleoside-triphosphate reductase. | Ribonucleoside-diphosphate reductase, alpha chain. | 0.708 |