EHR32520.1 protein (Helcococcus kunzii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

EHR32520.1

Hypothetical protein. (2001 aa)

Predicted Functional Partners:

EHR36305.1

0.945

EHR34158.1

0.945

EHR32641.1

0.824

EHR36316.1

0.761

EHR36320.1

0.761

EHR33986.1

0.756

EHR36314.1

0.750

EHR35852.1

0.743

EHR34689.1

0.695

EHR34417.1

0.695

Your Current Organism:

Helcococcus kunzii

NCBI taxonomy Id: 883114
Other names: H. kunzii ATCC 51366, Helcococcus kunzii ATCC 51366

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EHR32520.1	EHR32641.1	HMPREF9709_01451	HMPREF9709_01450	Hypothetical protein.	LPXTG-domain-containing protein cell wall anchor domain.	0.824
EHR32520.1	EHR33986.1	HMPREF9709_01451	HMPREF9709_00922	Hypothetical protein.	Hypothetical protein.	0.756
EHR32520.1	EHR34158.1	HMPREF9709_01451	HMPREF9709_01094	Hypothetical protein.	Hypothetical protein.	0.945
EHR32520.1	EHR34417.1	HMPREF9709_01451	HMPREF9709_00724	Hypothetical protein.	Hypothetical protein.	0.695
EHR32520.1	EHR34689.1	HMPREF9709_01451	HMPREF9709_00659	Hypothetical protein.	Hypothetical protein.	0.695
EHR32520.1	EHR35852.1	HMPREF9709_01451	HMPREF9709_00211	Hypothetical protein.	Hypothetical protein; Belongs to the peptidase S8 family.	0.743
EHR32520.1	EHR36305.1	HMPREF9709_01451	HMPREF9709_00060	Hypothetical protein.	Hypothetical protein.	0.945
EHR32520.1	EHR36314.1	HMPREF9709_01451	HMPREF9709_00069	Hypothetical protein.	Hypothetical protein.	0.750
EHR32520.1	EHR36316.1	HMPREF9709_01451	HMPREF9709_00071	Hypothetical protein.	Hypothetical protein.	0.761
EHR32520.1	EHR36320.1	HMPREF9709_01451	HMPREF9709_00075	Hypothetical protein.	Hypothetical protein.	0.761
EHR32641.1	EHR32520.1	HMPREF9709_01450	HMPREF9709_01451	LPXTG-domain-containing protein cell wall anchor domain.	Hypothetical protein.	0.824
EHR33986.1	EHR32520.1	HMPREF9709_00922	HMPREF9709_01451	Hypothetical protein.	Hypothetical protein.	0.756
EHR33986.1	EHR34158.1	HMPREF9709_00922	HMPREF9709_01094	Hypothetical protein.	Hypothetical protein.	0.588
EHR33986.1	EHR34417.1	HMPREF9709_00922	HMPREF9709_00724	Hypothetical protein.	Hypothetical protein.	0.977
EHR33986.1	EHR34689.1	HMPREF9709_00922	HMPREF9709_00659	Hypothetical protein.	Hypothetical protein.	0.945
EHR33986.1	EHR35852.1	HMPREF9709_00922	HMPREF9709_00211	Hypothetical protein.	Hypothetical protein; Belongs to the peptidase S8 family.	0.506
EHR33986.1	EHR36305.1	HMPREF9709_00922	HMPREF9709_00060	Hypothetical protein.	Hypothetical protein.	0.588
EHR33986.1	EHR36320.1	HMPREF9709_00922	HMPREF9709_00075	Hypothetical protein.	Hypothetical protein.	0.411
EHR34158.1	EHR32520.1	HMPREF9709_01094	HMPREF9709_01451	Hypothetical protein.	Hypothetical protein.	0.945
EHR34158.1	EHR33986.1	HMPREF9709_01094	HMPREF9709_00922	Hypothetical protein.	Hypothetical protein.	0.588

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

45

average node degree:

8.18

avg. local clustering coefficient:

0.962

expected number of edges:

10

PPI enrichment p-value:

1.55e-15

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0031204

Post-translational protein targeting to membrane, translocation

4 of 6

3.28

4.69

2.97e-09

GO:0045047

Protein targeting to ER

5 of 28

2.7

4.55

2.49e-09

GO:0006612

Protein targeting to membrane

5 of 51

2.44

4.16

6.70e-09

GO:0006614

SRP-dependent cotranslational protein targeting to membrane

4 of 17

2.82

3.98

4.00e-08

GO:0006616

SRP-dependent cotranslational protein targeting to membrane, translocation

3 of 5

3.23

3.36

8.22e-07

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0043022

Ribosome binding

4 of 61

2.27

2.52

1.25e-05

GO:0008320

Protein transmembrane transporter activity

2 of 13

2.64

1.13

0.0088

GO:0019838

Growth factor binding

2 of 18

2.5

1.12

0.0088

GO:0042562

Hormone binding

2 of 26

2.34

1.04

0.0119

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0140534

Endoplasmic reticulum protein-containing complex

7 of 74

2.43

6.44

3.60e-14

GO:0071256

Translocon complex

4 of 4

3.45

5.6

7.00e-11

GO:0005789

Endoplasmic reticulum membrane

11 of 581

1.73

4.5

1.14e-16

GO:0005784

Sec61 translocon complex

3 of 3

3.45

4.0

5.84e-08

GO:0008250

Oligosaccharyltransferase complex

3 of 10

2.93

3.38

6.25e-07

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:31634

Oligosaccharyltransferase complex, and Post-translational protein targeting to membrane, translocation

10 of 24

3.07

13.33

2.63e-26

CL:31636

Oligosaccharyltransferase complex, and Translocon-associated

8 of 18

3.1

10.68

7.22e-21

CL:31661

Mixed, incl. Sec61beta family, and Translocon-associated

5 of 5

3.45

6.95

2.28e-13

CL:31638

Oligosaccharyltransferase complex

3 of 11

2.89

5.12e-06

CL:31641

Oligosaccharyltransferase complex

2 of 5

3.05

1.68

0.00093

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04141

Protein processing in endoplasmic reticulum

10 of 303

1.97

5.9

1.62e-17

map03060

Protein export

4 of 39

2.46

3.66

8.41e-08

map04145

Phagosome

4 of 151

1.87

2.29

1.03e-05

map00510

N-Glycan biosynthesis

2 of 71

1.9

0.99

0.0120

map00513

Various types of N-glycan biosynthesis

2 of 80

1.85

0.98

0.0121

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-1799339

SRP-dependent cotranslational protein targeting to membrane

6 of 115

2.17

4.09

1.80e-09

MAP-9609523

Insertion of tail-anchored proteins into the endoplasmic reticulum membrane

3 of 17

2.7

2.59

1.62e-05

MAP-72766

Translation

6 of 322

1.72

2.56

3.76e-07

MAP-9609507

Protein localization

3 of 210

1.61

0.87

0.0163

MAP-392499

Metabolism of proteins

6 of 2399

0.85

0.54

0.0181

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0071256

Translocon complex

5 of 6

3.37

6.9

2.69e-13

GOCC:0005789

Endoplasmic reticulum membrane

9 of 199

2.11

6.09

7.43e-16

GOCC:0005784

Sec61 translocon complex

4 of 5

3.35

5.38

1.69e-10

GOCC:0005783

Endoplasmic reticulum

10 of 354

1.9

5.24

5.63e-16

GOCC:0098796

Membrane protein complex

8 of 516

1.64

3.15

1.69e-10

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0256

Endoplasmic reticulum

4 of 61

2.27

2.93

1.65e-06

KW-0811

Translocation

2 of 13

2.64

1.72

0.00069

KW-1133

Transmembrane helix

10 of 6441

0.64

0.55

0.00019

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF03911

Sec61beta family

2 of 2

3.45

1.62

0.0012

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR030671

Protein transport Sec61-beta/Sbh

2 of 2

3.45

1.37

0.0035

IPR016482

Protein transport protein SecG/Sec61-beta/Sbh

2 of 2

3.45

1.37

0.0035

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (28%) [HD]

Permalink

Network

Neighborhood

Experiments

Fusion

Databases

Cooccurrence

Textmining

Coexpression

© STRING Consortium 2024

Credits

Access

Info

About