EHR32293.1 protein (Helcococcus kunzii) - STRING interaction network

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second shell of interactors

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Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Score

EHR32293.1

PTS system, Fru family, IIC component. (342 aa)

Predicted Functional Partners:

EHR32295.1

0.999

EHR32549.1

0.996

EHR32294.1

0.996

EHR33271.1

0.985

EHR34010.1

0.982

EHR35072.1

0.980

EHR32584.1

0.980

EHR32340.1

0.980

EHR32557.1

0.970

EHR36275.1

0.969

Your Current Organism:

Helcococcus kunzii

NCBI taxonomy Id: 883114
Other names: H. kunzii ATCC 51366, Helcococcus kunzii ATCC 51366

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EHR32293.1	EHR32294.1	HMPREF9709_01574	HMPREF9709_01575	PTS system, Fru family, IIC component.	PTS system, Fru family, IIB component.	0.996
EHR32293.1	EHR32295.1	HMPREF9709_01574	HMPREF9709_01576	PTS system, Fru family, IIC component.	PTS system, fructose subfamily, IIA component.	0.999
EHR32293.1	EHR32340.1	HMPREF9709_01574	HMPREF9709_01621	PTS system, Fru family, IIC component.	PTS system, mannose/fructose/sorbose family, IIA component.	0.980
EHR32293.1	EHR32549.1	HMPREF9709_01574	HMPREF9709_01480	PTS system, Fru family, IIC component.	PTS system, fructose subfamily, IIA component.	0.996
EHR32293.1	EHR32557.1	HMPREF9709_01574	HMPREF9709_01488	PTS system, Fru family, IIC component.	PTS system, fructose subfamily, IIA component.	0.970
EHR32293.1	EHR32584.1	HMPREF9709_01574	HMPREF9709_01515	PTS system, Fru family, IIC component.	PTS system, mannose/fructose/sorbose family, IIA component.	0.980
EHR32293.1	EHR33271.1	HMPREF9709_01574	HMPREF9709_01315	PTS system, Fru family, IIC component.	Hypothetical protein.	0.985
EHR32293.1	EHR34010.1	HMPREF9709_01574	HMPREF9709_00946	PTS system, Fru family, IIC component.	Hypothetical protein.	0.982
EHR32293.1	EHR35072.1	HMPREF9709_01574	HMPREF9709_00498	PTS system, Fru family, IIC component.	PTS system, mannose/fructose/sorbose family, IIA component.	0.980
EHR32293.1	EHR36275.1	HMPREF9709_01574	HMPREF9709_00030	PTS system, Fru family, IIC component.	1-phosphofructokinase family hexose kinase; Belongs to the carbohydrate kinase PfkB family. LacC subfamily.	0.969
EHR32294.1	EHR32293.1	HMPREF9709_01575	HMPREF9709_01574	PTS system, Fru family, IIB component.	PTS system, Fru family, IIC component.	0.996
EHR32294.1	EHR32295.1	HMPREF9709_01575	HMPREF9709_01576	PTS system, Fru family, IIB component.	PTS system, fructose subfamily, IIA component.	0.994
EHR32294.1	EHR32340.1	HMPREF9709_01575	HMPREF9709_01621	PTS system, Fru family, IIB component.	PTS system, mannose/fructose/sorbose family, IIA component.	0.655
EHR32294.1	EHR32549.1	HMPREF9709_01575	HMPREF9709_01480	PTS system, Fru family, IIB component.	PTS system, fructose subfamily, IIA component.	0.739
EHR32294.1	EHR32557.1	HMPREF9709_01575	HMPREF9709_01488	PTS system, Fru family, IIB component.	PTS system, fructose subfamily, IIA component.	0.676
EHR32294.1	EHR32584.1	HMPREF9709_01575	HMPREF9709_01515	PTS system, Fru family, IIB component.	PTS system, mannose/fructose/sorbose family, IIA component.	0.655
EHR32294.1	EHR33271.1	HMPREF9709_01575	HMPREF9709_01315	PTS system, Fru family, IIB component.	Hypothetical protein.	0.770
EHR32294.1	EHR34010.1	HMPREF9709_01575	HMPREF9709_00946	PTS system, Fru family, IIB component.	Hypothetical protein.	0.823
EHR32294.1	EHR35072.1	HMPREF9709_01575	HMPREF9709_00498	PTS system, Fru family, IIB component.	PTS system, mannose/fructose/sorbose family, IIA component.	0.655
EHR32294.1	EHR36275.1	HMPREF9709_01575	HMPREF9709_00030	PTS system, Fru family, IIB component.	1-phosphofructokinase family hexose kinase; Belongs to the carbohydrate kinase PfkB family. LacC subfamily.	0.788

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Network Stats

number of nodes:

11

number of edges:

45

average node degree:

8.18

avg. local clustering coefficient:

0.849

expected number of edges:

11

PPI enrichment p-value:

1.04e-14

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0007165

Signal transduction

11 of 41

1.98

6.18

1.06e-18

GO:0000160

Phosphorelay signal transduction system

10 of 34

2.02

6.02

4.17e-17

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000155

Phosphorelay sensor kinase activity

8 of 13

2.34

6.34

1.92e-14

GO:0016772

Transferase activity, transferring phosphorus-containing groups

9 of 133

1.38

2.28

4.31e-10

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016021

Integral component of membrane

9 of 760

0.62

0.48

0.0023

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2926

Two-component regulatory system, and Histidine kinase domain

10 of 23

2.18

7.21

1.41e-18

CL:2928

Two-component regulatory system, and Histidine kinase domain

9 of 18

2.25

6.93

6.92e-17

CL:2931

Two-component regulatory system, and PAS domain

8 of 12

2.37

6.82

1.80e-15

CL:2923

Phosphorelay signal transduction system, and P-type ion transporter activity

11 of 35

2.04

6.74

1.59e-19

CL:2933

Histidine kinase domain, and Transcriptional regulatory protein, C terminal

3 of 5

2.32

2.12

9.31e-05

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

aka02020

Two-component system

4 of 79

1.25

0.87

0.0063

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0418

Kinase

9 of 67

1.67

3.58

2.78e-12

KW-0902

Two-component regulatory system

4 of 14

2.0

2.46

7.00e-06

KW-0067

ATP-binding

6 of 232

0.96

0.81

0.00089

KW-0597

Phosphoprotein

2 of 22

1.51

0.67

0.0435

KW-1133

Transmembrane helix

8 of 684

0.61

0.47

0.0033

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR005467

Histidine kinase domain

9 of 11

2.46

7.81

2.22e-17

IPR036890

Histidine kinase/HSP90-like ATPase superfamily

9 of 12

2.42

7.7

2.22e-17

IPR003594

Histidine kinase/HSP90-like ATPase

9 of 12

2.42

7.7

2.22e-17

IPR036097

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain superfamily

8 of 11

2.41

6.82

3.22e-15

IPR003661

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain

8 of 11

2.41

6.82

3.22e-15

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00387

Histidine kinase-like ATPases

9 of 11

2.46

8.28

1.41e-18

SM00388

His Kinase A (phosphoacceptor) domain

8 of 11

2.41

7.18

4.08e-16

SM00304

HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain

4 of 4

2.55

3.75

6.79e-08

SM00091

PAS domain

2 of 3

2.37

1.52

0.0015

SM00862

Transcriptional regulatory protein, C terminal

2 of 12

1.77

0.99

0.0109

(more ...)

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