node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EHR32081.1 | EHR32082.1 | HMPREF9709_01695 | HMPREF9709_01696 | RNA polymerase sigma-70 factor, sigma-B/F/G subfamily. | Hypothetical protein. | 0.995 |
EHR32081.1 | EHR32083.1 | HMPREF9709_01695 | HMPREF9709_01697 | RNA polymerase sigma-70 factor, sigma-B/F/G subfamily. | Anti-anti-sigma factor; Belongs to the anti-sigma-factor antagonist family. | 0.993 |
EHR32081.1 | EHR32087.1 | HMPREF9709_01695 | HMPREF9709_01701 | RNA polymerase sigma-70 factor, sigma-B/F/G subfamily. | S4 domain-containing protein YaaA. | 0.735 |
EHR32081.1 | EHR32088.1 | HMPREF9709_01695 | HMPREF9709_01702 | RNA polymerase sigma-70 factor, sigma-B/F/G subfamily. | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.842 |
EHR32081.1 | dnaA | HMPREF9709_01695 | HMPREF9709_01703 | RNA polymerase sigma-70 factor, sigma-B/F/G subfamily. | Chromosomal replication initiator protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. Belongs to the DnaA family. | 0.531 |
EHR32081.1 | gyrA | HMPREF9709_01695 | HMPREF9709_01698 | RNA polymerase sigma-70 factor, sigma-B/F/G subfamily. | DNA gyrase, A subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.814 |
EHR32081.1 | gyrB | HMPREF9709_01695 | HMPREF9709_01699 | RNA polymerase sigma-70 factor, sigma-B/F/G subfamily. | DNA gyrase, B subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.813 |
EHR32081.1 | recF | HMPREF9709_01695 | HMPREF9709_01700 | RNA polymerase sigma-70 factor, sigma-B/F/G subfamily. | DNA replication and repair protein RecF; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP. | 0.799 |
EHR32082.1 | EHR32081.1 | HMPREF9709_01696 | HMPREF9709_01695 | Hypothetical protein. | RNA polymerase sigma-70 factor, sigma-B/F/G subfamily. | 0.995 |
EHR32082.1 | EHR32083.1 | HMPREF9709_01696 | HMPREF9709_01697 | Hypothetical protein. | Anti-anti-sigma factor; Belongs to the anti-sigma-factor antagonist family. | 0.999 |
EHR32082.1 | EHR32087.1 | HMPREF9709_01696 | HMPREF9709_01701 | Hypothetical protein. | S4 domain-containing protein YaaA. | 0.735 |
EHR32082.1 | EHR32088.1 | HMPREF9709_01696 | HMPREF9709_01702 | Hypothetical protein. | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.817 |
EHR32082.1 | dnaA | HMPREF9709_01696 | HMPREF9709_01703 | Hypothetical protein. | Chromosomal replication initiator protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. Belongs to the DnaA family. | 0.536 |
EHR32082.1 | gyrA | HMPREF9709_01696 | HMPREF9709_01698 | Hypothetical protein. | DNA gyrase, A subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.781 |
EHR32082.1 | gyrB | HMPREF9709_01696 | HMPREF9709_01699 | Hypothetical protein. | DNA gyrase, B subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.776 |
EHR32082.1 | recF | HMPREF9709_01696 | HMPREF9709_01700 | Hypothetical protein. | DNA replication and repair protein RecF; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP. | 0.762 |
EHR32083.1 | EHR32081.1 | HMPREF9709_01697 | HMPREF9709_01695 | Anti-anti-sigma factor; Belongs to the anti-sigma-factor antagonist family. | RNA polymerase sigma-70 factor, sigma-B/F/G subfamily. | 0.993 |
EHR32083.1 | EHR32082.1 | HMPREF9709_01697 | HMPREF9709_01696 | Anti-anti-sigma factor; Belongs to the anti-sigma-factor antagonist family. | Hypothetical protein. | 0.999 |
EHR32083.1 | EHR32087.1 | HMPREF9709_01697 | HMPREF9709_01701 | Anti-anti-sigma factor; Belongs to the anti-sigma-factor antagonist family. | S4 domain-containing protein YaaA. | 0.735 |
EHR32083.1 | EHR32088.1 | HMPREF9709_01697 | HMPREF9709_01702 | Anti-anti-sigma factor; Belongs to the anti-sigma-factor antagonist family. | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.768 |