| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EKU78141.1 | EKU79073.1 | HMPREF9282_01422 | HMPREF9282_00870 | Uracil-xanthine permease. | Phosphoribosylformylglycinamidine synthase. | 0.653 |
| EKU78141.1 | carA | HMPREF9282_01422 | HMPREF9282_00167 | Uracil-xanthine permease. | Carbamoyl-phosphate synthase, small subunit; Belongs to the CarA family. | 0.912 |
| EKU78141.1 | carB | HMPREF9282_01422 | HMPREF9282_00166 | Uracil-xanthine permease. | Carbamoyl-phosphate synthase, large subunit; Belongs to the CarB family. | 0.871 |
| EKU78141.1 | pyrB | HMPREF9282_01422 | HMPREF9282_00169 | Uracil-xanthine permease. | Aspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | 0.966 |
| EKU78141.1 | pyrC | HMPREF9282_01422 | HMPREF9282_00168 | Uracil-xanthine permease. | Dihydroorotase, multifunctional complex type; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. | 0.937 |
| EKU78141.1 | pyrD | HMPREF9282_01422 | HMPREF9282_00164 | Uracil-xanthine permease. | Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate. | 0.889 |
| EKU78141.1 | pyrE | HMPREF9282_01422 | HMPREF9282_01349 | Uracil-xanthine permease. | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | 0.926 |
| EKU78141.1 | pyrF | HMPREF9282_01422 | HMPREF9282_01350 | Uracil-xanthine permease. | Orotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. | 0.931 |
| EKU78141.1 | pyrK | HMPREF9282_01422 | HMPREF9282_00165 | Uracil-xanthine permease. | Hypothetical protein; Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+). | 0.712 |
| EKU78141.1 | pyrR | HMPREF9282_01422 | HMPREF9282_00241 | Uracil-xanthine permease. | Hypothetical protein; Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant; Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily. | 0.948 |
| EKU79073.1 | EKU78141.1 | HMPREF9282_00870 | HMPREF9282_01422 | Phosphoribosylformylglycinamidine synthase. | Uracil-xanthine permease. | 0.653 |
| EKU79073.1 | carA | HMPREF9282_00870 | HMPREF9282_00167 | Phosphoribosylformylglycinamidine synthase. | Carbamoyl-phosphate synthase, small subunit; Belongs to the CarA family. | 0.982 |
| EKU79073.1 | carB | HMPREF9282_00870 | HMPREF9282_00166 | Phosphoribosylformylglycinamidine synthase. | Carbamoyl-phosphate synthase, large subunit; Belongs to the CarB family. | 0.864 |
| EKU79073.1 | pyrB | HMPREF9282_00870 | HMPREF9282_00169 | Phosphoribosylformylglycinamidine synthase. | Aspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | 0.610 |
| EKU79073.1 | pyrC | HMPREF9282_00870 | HMPREF9282_00168 | Phosphoribosylformylglycinamidine synthase. | Dihydroorotase, multifunctional complex type; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. | 0.556 |
| EKU79073.1 | pyrD | HMPREF9282_00870 | HMPREF9282_00164 | Phosphoribosylformylglycinamidine synthase. | Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate. | 0.595 |
| EKU79073.1 | pyrE | HMPREF9282_00870 | HMPREF9282_01349 | Phosphoribosylformylglycinamidine synthase. | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | 0.616 |
| EKU79073.1 | pyrF | HMPREF9282_00870 | HMPREF9282_01350 | Phosphoribosylformylglycinamidine synthase. | Orotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. | 0.580 |
| EKU79073.1 | pyrK | HMPREF9282_00870 | HMPREF9282_00165 | Phosphoribosylformylglycinamidine synthase. | Hypothetical protein; Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+). | 0.543 |
| EKU79073.1 | pyrR | HMPREF9282_00870 | HMPREF9282_00241 | Phosphoribosylformylglycinamidine synthase. | Hypothetical protein; Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant; Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily. | 0.511 |