EPD33374.1 protein (Propionimicrobium lymphophilum)

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second shell of interactors

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

EPD33374.1

biotin-[acetyl-CoA-carboxylase] ligase. (257 aa)

Predicted Functional Partners:

EPD33369.1

0.991

EPD33373.1

0.970

EPD33609.1

0.958

EPD33607.1

0.934

EPD33372.1

0.800

EPD33710.1

0.775

EPD32505.1

0.767

EPD33371.1

0.653

ribA

0.640

EPD32480.1

0.623

Your Current Organism:

Propionimicrobium lymphophilum

NCBI taxonomy Id: 883161
Other names: P. lymphophilum ACS-093-V-SCH5, Propionimicrobium lymphophilum ACS-093-V-SCH5

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EPD32480.1	EPD33374.1	HMPREF9306_02052	HMPREF9306_00914	Hypothetical protein.	biotin-[acetyl-CoA-carboxylase] ligase.	0.623
EPD32505.1	EPD33369.1	HMPREF9306_02077	HMPREF9306_00909	Hypothetical protein.	Hypothetical protein.	0.795
EPD32505.1	EPD33374.1	HMPREF9306_02077	HMPREF9306_00914	Hypothetical protein.	biotin-[acetyl-CoA-carboxylase] ligase.	0.767
EPD32505.1	EPD33710.1	HMPREF9306_02077	HMPREF9306_00468	Hypothetical protein.	NAD+ synthetase.	0.976
EPD33369.1	EPD32505.1	HMPREF9306_00909	HMPREF9306_02077	Hypothetical protein.	Hypothetical protein.	0.795
EPD33369.1	EPD33372.1	HMPREF9306_00909	HMPREF9306_00912	Hypothetical protein.	Hypothetical protein.	0.731
EPD33369.1	EPD33373.1	HMPREF9306_00909	HMPREF9306_00913	Hypothetical protein.	Hypothetical protein.	0.999
EPD33369.1	EPD33374.1	HMPREF9306_00909	HMPREF9306_00914	Hypothetical protein.	biotin-[acetyl-CoA-carboxylase] ligase.	0.991
EPD33369.1	EPD33607.1	HMPREF9306_00909	HMPREF9306_00361	Hypothetical protein.	Hypothetical protein.	0.999
EPD33369.1	EPD33609.1	HMPREF9306_00909	HMPREF9306_00363	Hypothetical protein.	Hypothetical protein.	0.922
EPD33369.1	EPD33710.1	HMPREF9306_00909	HMPREF9306_00468	Hypothetical protein.	NAD+ synthetase.	0.605
EPD33371.1	EPD33372.1	HMPREF9306_00911	HMPREF9306_00912	Septum formation protein Maf; Nucleoside triphosphate pyrophosphatase. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.	Hypothetical protein.	0.841
EPD33371.1	EPD33373.1	HMPREF9306_00911	HMPREF9306_00913	Septum formation protein Maf; Nucleoside triphosphate pyrophosphatase. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.	Hypothetical protein.	0.805
EPD33371.1	EPD33374.1	HMPREF9306_00911	HMPREF9306_00914	Septum formation protein Maf; Nucleoside triphosphate pyrophosphatase. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.	biotin-[acetyl-CoA-carboxylase] ligase.	0.653
EPD33371.1	EPD33710.1	HMPREF9306_00911	HMPREF9306_00468	Septum formation protein Maf; Nucleoside triphosphate pyrophosphatase. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.	NAD+ synthetase.	0.447
EPD33372.1	EPD33369.1	HMPREF9306_00912	HMPREF9306_00909	Hypothetical protein.	Hypothetical protein.	0.731
EPD33372.1	EPD33371.1	HMPREF9306_00912	HMPREF9306_00911	Hypothetical protein.	Septum formation protein Maf; Nucleoside triphosphate pyrophosphatase. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.	0.841
EPD33372.1	EPD33373.1	HMPREF9306_00912	HMPREF9306_00913	Hypothetical protein.	Hypothetical protein.	0.877
EPD33372.1	EPD33374.1	HMPREF9306_00912	HMPREF9306_00914	Hypothetical protein.	biotin-[acetyl-CoA-carboxylase] ligase.	0.800
EPD33372.1	EPD33607.1	HMPREF9306_00912	HMPREF9306_00361	Hypothetical protein.	Hypothetical protein.	0.414

page 1 of 3

Network Stats

number of nodes:

5

number of edges:

7

average node degree:

2.8

avg. local clustering coefficient:

0.9

expected number of edges:

4

PPI enrichment p-value:

0.148

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000209

Protein polyubiquitination

7 of 225

1.86

3.42

3.18e-09

GO:0016567

Protein ubiquitination

10 of 742

1.49

2.77

4.28e-11

GO:0070534

Protein K63-linked ubiquitination

3 of 33

2.32

1.95

0.00020

GO:0043161

Proteasome-mediated ubiquitin-dependent protein catabolic process

5 of 307

1.58

1.68

8.05e-05

GO:0019941

Modification-dependent protein catabolic process

6 of 608

1.36

1.46

6.65e-05

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0019787

Ubiquitin-like protein transferase activity

7 of 511

1.5

2.05

1.17e-06

GO:0004842

Ubiquitin-protein transferase activity

6 of 490

1.45

1.65

3.09e-05

GO:0061659

Ubiquitin-like protein ligase activity

4 of 362

1.41

0.86

0.0117

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:10284

Mixed, incl. Ubiquitin-like protein conjugating enzyme activity, and Protein sumoylation

6 of 103

2.13

3.69

1.34e-08

CL:10286

Mixed, incl. Ubiquitin conjugating enzyme activity, and Negative regulation of histone ubiquitination

5 of 60

2.28

3.6

5.82e-08

CL:10288

Mixed, incl. Ubiquitin conjugating enzyme activity, and Ubiquitin-dependent protein catabolic process via the N-end rule pathway

4 of 53

2.24

2.63

6.73e-06

CL:10289

Mixed, incl. Ubiquitin conjugating enzyme activity, and Ubiquitin-activating enzyme E1

3 of 42

2.22

1.67

0.00066

CL:10291

Ubiquitin conjugating enzyme activity, and Ubiquitin-activating enzyme E1

2 of 23

2.3

0.8

0.0346

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

dre04120

Ubiquitin mediated proteolysis

7 of 154

2.02

4.48

1.94e-11

dre04141

Protein processing in endoplasmic reticulum

3 of 197

1.55

1.02

0.0063

dre04137

Mitophagy - animal

2 of 87

1.72

0.74

0.0364

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

DRE-983168

Antigen processing: Ubiquitination & Proteasome degradation

7 of 303

1.73

2.92

1.92e-08

DRE-5696395

Formation of Incision Complex in GG-NER

3 of 42

2.22

1.81

0.00034

DRE-9708530

Regulation of BACH1 activity

2 of 10

2.66

1.45

0.0023

DRE-69052

Switching of origins to a post-replicative state

3 of 82

1.93

1.43

0.0014

DRE-975144

IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation

2 of 14

2.52

1.37

0.0030

(more ...)

WikiPathways

pathway

description

count in network

strength

signal

false discovery rate

WP324

Cytoplasmic ribosomal proteins

2 of 78

1.77

0.83

0.0243

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0035370

UBC13-UEV1A complex

2 of 2

3.36

1.55

0.0016

GOCC:1990234

Transferase complex

5 of 805

1.16

0.78

0.0088

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR013083

Zinc finger, RING/FYVE/PHD-type

5 of 371

1.49

1.21

0.0016

IPR019954

Ubiquitin conserved site

2 of 7

2.82

1.08

0.0113

IPR019956

Ubiquitin domain

2 of 9

2.71

1.04

0.0130

IPR011332

Zinc-binding ribosomal protein

2 of 9

2.71

1.04

0.0130

IPR001841

Zinc finger, RING-type

4 of 248

1.57

0.98

0.0082

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00212

Ubiquitin-conjugating enzyme E2, catalytic domain homologues

3 of 50

2.14

1.54

0.0011

SM00184

Ring finger

4 of 438

1.32

0.84

0.0108

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