EPD32142.1 protein (Propionimicrobium lymphophilum)

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Predicted Interactions

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EPD32142.1

Ferredoxin; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. (105 aa)

Predicted Functional Partners:

EPD32504.1

0.996

EPD33367.1

0.994

EPD32141.1

0.934

EPD32505.1

0.885

EPD32408.1

0.864

EPD34028.1

0.762

EPD33491.1

0.760

EPD32132.1

0.673

EPD33445.1

0.670

ldh

0.638

Your Current Organism:

Propionimicrobium lymphophilum

NCBI taxonomy Id: 883161
Other names: P. lymphophilum ACS-093-V-SCH5, Propionimicrobium lymphophilum ACS-093-V-SCH5

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EPD32132.1	EPD32142.1	HMPREF9306_01696	HMPREF9306_01706	Hypothetical protein; Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP; Belongs to the Mrp/NBP35 ATP-binding proteins family.	Ferredoxin; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.	0.673
EPD32132.1	EPD32408.1	HMPREF9306_01696	HMPREF9306_01979	Hypothetical protein; Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP; Belongs to the Mrp/NBP35 ATP-binding proteins family.	2-oxoacid:acceptor oxidoreductase, alpha subunit.	0.457
EPD32132.1	EPD32504.1	HMPREF9306_01696	HMPREF9306_02076	Hypothetical protein; Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP; Belongs to the Mrp/NBP35 ATP-binding proteins family.	Pyruvate:ferredoxin (flavodoxin) oxidoreductase.	0.888
EPD32132.1	EPD32505.1	HMPREF9306_01696	HMPREF9306_02077	Hypothetical protein; Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP; Belongs to the Mrp/NBP35 ATP-binding proteins family.	Hypothetical protein.	0.808
EPD32132.1	EPD33367.1	HMPREF9306_01696	HMPREF9306_00907	Hypothetical protein; Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP; Belongs to the Mrp/NBP35 ATP-binding proteins family.	Pyruvate:ferredoxin (flavodoxin) oxidoreductase.	0.977
EPD32141.1	EPD32142.1	HMPREF9306_01705	HMPREF9306_01706	Succinyldiaminopimelate transaminase.	Ferredoxin; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.	0.934
EPD32141.1	EPD32408.1	HMPREF9306_01705	HMPREF9306_01979	Succinyldiaminopimelate transaminase.	2-oxoacid:acceptor oxidoreductase, alpha subunit.	0.683
EPD32141.1	EPD32504.1	HMPREF9306_01705	HMPREF9306_02076	Succinyldiaminopimelate transaminase.	Pyruvate:ferredoxin (flavodoxin) oxidoreductase.	0.942
EPD32141.1	EPD32505.1	HMPREF9306_01705	HMPREF9306_02077	Succinyldiaminopimelate transaminase.	Hypothetical protein.	0.834
EPD32141.1	EPD33367.1	HMPREF9306_01705	HMPREF9306_00907	Succinyldiaminopimelate transaminase.	Pyruvate:ferredoxin (flavodoxin) oxidoreductase.	0.919
EPD32141.1	EPD33445.1	HMPREF9306_01705	HMPREF9306_00985	Succinyldiaminopimelate transaminase.	Hypothetical protein.	0.713
EPD32142.1	EPD32132.1	HMPREF9306_01706	HMPREF9306_01696	Ferredoxin; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.	Hypothetical protein; Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP; Belongs to the Mrp/NBP35 ATP-binding proteins family.	0.673
EPD32142.1	EPD32141.1	HMPREF9306_01706	HMPREF9306_01705	Ferredoxin; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.	Succinyldiaminopimelate transaminase.	0.934
EPD32142.1	EPD32408.1	HMPREF9306_01706	HMPREF9306_01979	Ferredoxin; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.	2-oxoacid:acceptor oxidoreductase, alpha subunit.	0.864
EPD32142.1	EPD32504.1	HMPREF9306_01706	HMPREF9306_02076	Ferredoxin; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.	Pyruvate:ferredoxin (flavodoxin) oxidoreductase.	0.996
EPD32142.1	EPD32505.1	HMPREF9306_01706	HMPREF9306_02077	Ferredoxin; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.	Hypothetical protein.	0.885
EPD32142.1	EPD33367.1	HMPREF9306_01706	HMPREF9306_00907	Ferredoxin; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.	Pyruvate:ferredoxin (flavodoxin) oxidoreductase.	0.994
EPD32142.1	EPD33445.1	HMPREF9306_01706	HMPREF9306_00985	Ferredoxin; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.	Hypothetical protein.	0.670
EPD32142.1	EPD33491.1	HMPREF9306_01706	HMPREF9306_01032	Ferredoxin; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.	Isocitrate dehydrogenase, NADP-dependent; Belongs to the monomeric-type IDH family.	0.760
EPD32142.1	EPD34028.1	HMPREF9306_01706	HMPREF9306_00062	Ferredoxin; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.	Phosphate acetyltransferase.	0.762

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Network Stats

number of nodes:

11

number of edges:

41

average node degree:

7.45

avg. local clustering coefficient:

0.817

expected number of edges:

16

PPI enrichment p-value:

9.53e-08

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0046486

Glycerolipid metabolic process

6 of 179

1.9

2.95

1.81e-07

GO:0006629

Lipid metabolic process

8 of 742

1.41

2.03

1.81e-07

GO:0055091

Phospholipid homeostasis

2 of 2

3.38

1.84

0.00049

GO:0045017

Glycerolipid biosynthetic process

4 of 139

1.84

1.72

0.00024

GO:0140042

Lipid droplet formation

2 of 4

3.08

1.67

0.00096

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008374

O-acyltransferase activity

4 of 35

2.44

2.95

2.27e-06

GO:0102545

Phosphatidyl phospholipase B activity

2 of 2

3.38

1.88

0.00041

GO:0046027

Phospholipid:diacylglycerol acyltransferase activity

2 of 2

3.38

1.88

0.00041

GO:0003841

1-acylglycerol-3-phosphate O-acyltransferase activity

2 of 3

3.2

1.87

0.00043

GO:0004620

Phospholipase activity

3 of 36

2.3

1.79

0.00041

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0097038

Perinuclear endoplasmic reticulum

2 of 8

2.78

1.32

0.0040

GO:0032541

Cortical endoplasmic reticulum

2 of 14

2.53

1.31

0.0040

GO:0005637

Nuclear inner membrane

2 of 13

2.57

1.31

0.0040

GO:0005811

Lipid droplet

2 of 53

1.96

0.9

0.0195

GO:0019866

Organelle inner membrane

3 of 319

1.35

0.76

0.0205

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:20219

Glycerophospholipid metabolism, and Fatty acid biosynthesis

7 of 106

2.2

4.89

1.99e-11

CL:20220

Glycerophospholipid metabolism, and Fatty acid biosynthesis

5 of 88

2.13

3.14

3.08e-07

CL:20221

Mixed, incl. Triglyceride metabolic process, and Phosphate acyltransferases

4 of 52

2.26

2.68

5.48e-06

CL:20236

1-acylglycerol-3-phosphate O-acyltransferase activity, and Glycerophosphodiester phosphodiesterase domain

2 of 5

2.98

1.46

0.0023

CL:20400

Animal haem peroxidase, and Acyl chain remodelling of PC

2 of 6

2.9

1.45

0.0024

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00564

Glycerophospholipid metabolism

6 of 186

1.89

3.34

9.50e-09

map00561

Glycerolipid metabolism

4 of 106

1.96

2.42

7.09e-06

map00565

Ether lipid metabolism

2 of 63

1.88

0.92

0.0165

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-1482788

Acyl chain remodelling of PC

4 of 10

2.98

4.4

7.86e-09

MAP-1483257

Phospholipid metabolism

7 of 159

2.02

4.25

1.08e-10

MAP-1482839

Acyl chain remodelling of PE

4 of 14

2.83

4.19

1.60e-08

MAP-1483206

Glycerophospholipid biosynthesis

5 of 90

2.12

3.42

5.96e-08

MAP-1482801

Acyl chain remodelling of PS

3 of 7

3.01

3.28

1.03e-06

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005783

Endoplasmic reticulum

6 of 367

1.59

2.09

3.48e-06

GOCC:0097038

Perinuclear endoplasmic reticulum

2 of 14

2.53

1.2

0.0065

GOCC:0005737

Cytoplasm

8 of 4349

0.64

0.43

0.0148

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0443

Lipid metabolism

4 of 38

2.4

3.27

4.44e-07

KW-0442

Lipid degradation

3 of 9

2.9

3.18

1.44e-06

KW-1133

Transmembrane helix

9 of 3683

0.77

0.7

7.08e-05

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02450

Lecithin:cholesterol acyltransferase

2 of 2

3.38

1.6

0.0013

PF01734

Patatin-like phospholipase

2 of 3

3.2

1.6

0.0013

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR016035

Acyl transferase/acyl hydrolase/lysophospholipase

3 of 9

2.9

2.39

4.44e-05

IPR003386

Lecithin:cholesterol/phospholipid:diacylglycerol acyltransferase

2 of 2

3.38

1.53

0.0018

IPR002641

Patatin-like phospholipase domain

2 of 3

3.2

1.5

0.0020

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