Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
SPRY4Sprouty RTK signaling antagonist 4. (299 aa)    
Predicted Functional Partners:
CBLB
Cbl proto-oncogene B.
    
 0.688
CBL
Cbl proto-oncogene.
    
 0.688
IL17RD
Interleukin 17 receptor D.
   
  
 0.670
FGF8
Fibroblast growth factor; Belongs to the heparin-binding growth factors family.
   
  
 0.599
DUSP6
Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.
   
  
 0.577
GRB2
Growth factor receptor bound protein 2.
    
 0.547
LAPTM4B
Lysosomal protein transmembrane 4 beta.
    
   0.532
PTPN11
Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.
    
 0.530
RAF1
Raf-1 proto-oncogene, serine/threonine kinase.
    
 0.513
TRIP4
Thyroid hormone receptor interactor 4.
      
 0.503
Your Current Organism:
Anas platyrhynchos
NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard
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