node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
APEX1 | FEN1 | ENSAPLP00000018420 | ENSAPLP00000001147 | DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | 0.951 |
APEX1 | LIG1 | ENSAPLP00000018420 | ENSAPLP00000012998 | DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. | DNA ligase. | 0.928 |
APEX1 | MRE11 | ENSAPLP00000018420 | ENSAPLP00000021869 | DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. | MRE11 homolog, double strand break repair nuclease. | 0.434 |
APEX1 | PCNA | ENSAPLP00000018420 | ENSAPLP00000028238 | DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. | 0.863 |
APEX1 | POLD2 | ENSAPLP00000018420 | ENSAPLP00000021348 | DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. | DNA polymerase delta 2, accessory subunit. | 0.781 |
APEX1 | RFC3 | ENSAPLP00000018420 | ENSAPLP00000010116 | DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. | Replication factor C subunit 3. | 0.639 |
APEX1 | RFC4 | ENSAPLP00000018420 | ENSAPLP00000007062 | DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. | Replication factor C subunit 4. | 0.669 |
APEX1 | U3I2H1_ANAPP | ENSAPLP00000018420 | ENSAPLP00000001441 | DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. | Uncharacterized protein. | 0.568 |
DNA2 | ENSAPLP00000026881 | ENSAPLP00000015481 | ENSAPLP00000026881 | DNA replication helicase/nuclease 2. | Zinc-hook domain-containing protein. | 0.756 |
DNA2 | FEN1 | ENSAPLP00000015481 | ENSAPLP00000001147 | DNA replication helicase/nuclease 2. | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | 0.969 |
DNA2 | LIG1 | ENSAPLP00000015481 | ENSAPLP00000012998 | DNA replication helicase/nuclease 2. | DNA ligase. | 0.673 |
DNA2 | MRE11 | ENSAPLP00000015481 | ENSAPLP00000021869 | DNA replication helicase/nuclease 2. | MRE11 homolog, double strand break repair nuclease. | 0.883 |
DNA2 | PCNA | ENSAPLP00000015481 | ENSAPLP00000028238 | DNA replication helicase/nuclease 2. | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. | 0.691 |
DNA2 | POLD2 | ENSAPLP00000015481 | ENSAPLP00000021348 | DNA replication helicase/nuclease 2. | DNA polymerase delta 2, accessory subunit. | 0.837 |
DNA2 | RFC3 | ENSAPLP00000015481 | ENSAPLP00000010116 | DNA replication helicase/nuclease 2. | Replication factor C subunit 3. | 0.795 |
DNA2 | RFC4 | ENSAPLP00000015481 | ENSAPLP00000007062 | DNA replication helicase/nuclease 2. | Replication factor C subunit 4. | 0.778 |
DNA2 | U3I2H1_ANAPP | ENSAPLP00000015481 | ENSAPLP00000001441 | DNA replication helicase/nuclease 2. | Uncharacterized protein. | 0.996 |
ENSAPLP00000026881 | DNA2 | ENSAPLP00000026881 | ENSAPLP00000015481 | Zinc-hook domain-containing protein. | DNA replication helicase/nuclease 2. | 0.756 |
ENSAPLP00000026881 | FEN1 | ENSAPLP00000026881 | ENSAPLP00000001147 | Zinc-hook domain-containing protein. | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | 0.912 |
ENSAPLP00000026881 | LIG1 | ENSAPLP00000026881 | ENSAPLP00000012998 | Zinc-hook domain-containing protein. | DNA ligase. | 0.669 |