RNASEH1 protein (Anas platyrhynchos) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

RNASEH1

Ribonuclease H1; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (307 aa)

Predicted Functional Partners:

SETX

0.779

ADI1

0.744

SSBP1

0.728

TELO2

0.686

POLA1

0.684

RFC3

0.668

RNASEH2B

0.631

ENSAPLP00000028196

0.626

RPA1

0.625

PIF1

0.619

Your Current Organism:

Anas platyrhynchos

NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADI1	ENSAPLP00000028196	ENSAPLP00000017054	ENSAPLP00000028196	1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase; Catalyzes the formation of formate and 2-keto-4- methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). Also down-regulates cell migration mediated by MMP14. Belongs to the acireductone dioxygenase (ARD) family.	Gp_dh_C domain-containing protein.	0.419
ADI1	RNASEH1	ENSAPLP00000017054	ENSAPLP00000001433	1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase; Catalyzes the formation of formate and 2-keto-4- methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). Also down-regulates cell migration mediated by MMP14. Belongs to the acireductone dioxygenase (ARD) family.	Ribonuclease H1; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.	0.744
ENSAPLP00000028196	ADI1	ENSAPLP00000028196	ENSAPLP00000017054	Gp_dh_C domain-containing protein.	1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase; Catalyzes the formation of formate and 2-keto-4- methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). Also down-regulates cell migration mediated by MMP14. Belongs to the acireductone dioxygenase (ARD) family.	0.419
ENSAPLP00000028196	POLA1	ENSAPLP00000028196	ENSAPLP00000008748	Gp_dh_C domain-containing protein.	DNA polymerase.	0.483
ENSAPLP00000028196	RNASEH1	ENSAPLP00000028196	ENSAPLP00000001433	Gp_dh_C domain-containing protein.	Ribonuclease H1; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.	0.626
PIF1	POLA1	ENSAPLP00000008751	ENSAPLP00000008748	ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability.	DNA polymerase.	0.642
PIF1	RNASEH1	ENSAPLP00000008751	ENSAPLP00000001433	ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability.	Ribonuclease H1; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.	0.619
PIF1	RPA1	ENSAPLP00000008751	ENSAPLP00000030765	ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.699
PIF1	SETX	ENSAPLP00000008751	ENSAPLP00000016180	ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability.	Senataxin.	0.562
PIF1	SSBP1	ENSAPLP00000008751	ENSAPLP00000029338	ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability.	Single stranded DNA binding protein 1.	0.627
POLA1	ENSAPLP00000028196	ENSAPLP00000008748	ENSAPLP00000028196	DNA polymerase.	Gp_dh_C domain-containing protein.	0.483
POLA1	PIF1	ENSAPLP00000008748	ENSAPLP00000008751	DNA polymerase.	ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability.	0.642
POLA1	RFC3	ENSAPLP00000008748	ENSAPLP00000010116	DNA polymerase.	Replication factor C subunit 3.	0.866
POLA1	RNASEH1	ENSAPLP00000008748	ENSAPLP00000001433	DNA polymerase.	Ribonuclease H1; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.	0.684
POLA1	RNASEH2B	ENSAPLP00000008748	ENSAPLP00000031738	DNA polymerase.	Ribonuclease H2 subunit B.	0.420
POLA1	RPA1	ENSAPLP00000008748	ENSAPLP00000030765	DNA polymerase.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.955
RFC3	POLA1	ENSAPLP00000010116	ENSAPLP00000008748	Replication factor C subunit 3.	DNA polymerase.	0.866
RFC3	RNASEH1	ENSAPLP00000010116	ENSAPLP00000001433	Replication factor C subunit 3.	Ribonuclease H1; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.	0.668
RFC3	RNASEH2B	ENSAPLP00000010116	ENSAPLP00000031738	Replication factor C subunit 3.	Ribonuclease H2 subunit B.	0.624
RFC3	RPA1	ENSAPLP00000010116	ENSAPLP00000030765	Replication factor C subunit 3.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.742