U3I3G6_ANAPP protein (Anas platyrhynchos) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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Score

U3I3G6_ANAPP

G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (439 aa)

Predicted Functional Partners:

QRFP

0.520

GNG11

0.501

GNB3

0.457

GNB1

0.457

GNB4

0.457

GNB5

0.457

GNGT2

0.452

GRK7

0.438

U3I0H3_ANAPP

0.428

U3IZH6_ANAPP

0.428

Your Current Organism:

Anas platyrhynchos

NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
GNB1	GNB3	ENSAPLP00000010816	ENSAPLP00000002795	G protein subunit beta 1.	G protein subunit beta 3.	0.432
GNB1	GNB4	ENSAPLP00000010816	ENSAPLP00000012022	G protein subunit beta 1.	G protein subunit beta 4.	0.432
GNB1	GNB5	ENSAPLP00000010816	ENSAPLP00000016983	G protein subunit beta 1.	G protein subunit beta 5.	0.417
GNB1	GNG11	ENSAPLP00000010816	ENSAPLP00000022549	G protein subunit beta 1.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.940
GNB1	GNGT2	ENSAPLP00000010816	ENSAPLP00000012380	G protein subunit beta 1.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.879
GNB1	GRK7	ENSAPLP00000010816	ENSAPLP00000005881	G protein subunit beta 1.	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.	0.596
GNB1	U3I3G6_ANAPP	ENSAPLP00000010816	ENSAPLP00000001787	G protein subunit beta 1.	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	0.457
GNB3	GNB1	ENSAPLP00000002795	ENSAPLP00000010816	G protein subunit beta 3.	G protein subunit beta 1.	0.432
GNB3	GNB4	ENSAPLP00000002795	ENSAPLP00000012022	G protein subunit beta 3.	G protein subunit beta 4.	0.433
GNB3	GNB5	ENSAPLP00000002795	ENSAPLP00000016983	G protein subunit beta 3.	G protein subunit beta 5.	0.406
GNB3	GNG11	ENSAPLP00000002795	ENSAPLP00000022549	G protein subunit beta 3.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.911
GNB3	GNGT2	ENSAPLP00000002795	ENSAPLP00000012380	G protein subunit beta 3.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.948
GNB3	GRK7	ENSAPLP00000002795	ENSAPLP00000005881	G protein subunit beta 3.	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.	0.596
GNB3	U3I3G6_ANAPP	ENSAPLP00000002795	ENSAPLP00000001787	G protein subunit beta 3.	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	0.457
GNB4	GNB1	ENSAPLP00000012022	ENSAPLP00000010816	G protein subunit beta 4.	G protein subunit beta 1.	0.432
GNB4	GNB3	ENSAPLP00000012022	ENSAPLP00000002795	G protein subunit beta 4.	G protein subunit beta 3.	0.433
GNB4	GNB5	ENSAPLP00000012022	ENSAPLP00000016983	G protein subunit beta 4.	G protein subunit beta 5.	0.416
GNB4	GNG11	ENSAPLP00000012022	ENSAPLP00000022549	G protein subunit beta 4.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.940
GNB4	GNGT2	ENSAPLP00000012022	ENSAPLP00000012380	G protein subunit beta 4.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.928
GNB4	GRK7	ENSAPLP00000012022	ENSAPLP00000005881	G protein subunit beta 4.	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.	0.596

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Network Stats

number of nodes:

3

number of edges:

3

average node degree:

2

avg. local clustering coefficient:

1

expected number of edges:

2

PPI enrichment p-value:

0.211

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0031072

Heat shock protein binding

3 of 73

1.83

0.82

0.0287

GO:0008276

Protein methyltransferase activity

3 of 78

1.81

0.82

0.0287

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0035869

Ciliary transition zone

3 of 70

1.85

1.0

0.0126

GO:0036038

MKS complex

2 of 13

2.41

0.93

0.0226

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:29744

Lysine methyltransferase, and FAM86, N-terminal

4 of 12

2.74

3.52

4.42e-07

CL:16441

MKS complex, and Tectonic

3 of 5

3.0

2.93

6.48e-06

CL:29746

Lysine methyltransferase, and KOW (Kyprides, Ouzounis, Woese) motif.

3 of 6

2.92

2.87

8.09e-06

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-8876725

Protein methylation

6 of 22

2.66

6.01

4.49e-12

MAP-156902

Peptide chain elongation

2 of 2

3.22

1.6

0.0016

MAP-156842

Eukaryotic Translation Elongation

2 of 5

2.82

1.38

0.0038

MAP-5358493

Synthesis of diphthamide-EEF2

2 of 9

2.57

1.22

0.0068

MAP-5620912

Anchoring of the basal body to the plasma membrane

3 of 103

1.68

1.05

0.0081

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0036038

MKS complex

3 of 15

2.52

2.05

0.00020

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF10294

Lysine methyltransferase

2 of 6

2.74

1.0

0.0177

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR019410

Lysine methyltransferase

3 of 8

2.79

2.14

0.00016

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