Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
B2MBeta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (122 aa)    
Predicted Functional Partners:
ENSAPLP00000026233
Ig-like domain-containing protein; Belongs to the MHC class I family.
   
 0.973
U3ITP1_ANAPP
Ig-like domain-containing protein; Belongs to the MHC class I family.
   
 0.958
ENSAPLP00000019362
Ig-like domain-containing protein; Belongs to the MHC class I family.
   
 0.958
RPA3
Replication protein A3.
   
 0.958
RPA1
Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.
   
 0.953
U3J601_ANAPP
Ig-like domain-containing protein; Belongs to the MHC class I family.
   
 0.937
PDIA3
Protein disulfide-isomerase.
    
 0.898
PCNA
Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.
   
 0.896
DNA2
DNA replication helicase/nuclease 2.
   
 0.894
RAD52
RAD52 homolog, DNA repair protein.
    
 0.891
Your Current Organism:
Anas platyrhynchos
NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard
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