STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LAG3Lymphocyte activating 3. (505 aa)    
Predicted Functional Partners:
USP5
Ubiquitin carboxyl-terminal hydrolase.
      
 0.871
CTLA4
Cytotoxic T-lymphocyte associated protein 4.
   
  
 0.789
CD4
Ig-like domain-containing protein.
   
  
 0.777
PDCD1
Ig-like domain-containing protein.
   
 
 0.773
CD274
Uncharacterized protein.
   
 
 0.734
IFNG
Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.
   
  
 0.715
PDCD1LG2
Uncharacterized protein.
   
 
 0.695
FGL1
Fibrinogen like 1.
    
 
 0.648
TPI1
Triosephosphate isomerase.
      
 0.627
USP13
Ubiquitin carboxyl-terminal hydrolase.
      
 0.617
Your Current Organism:
Anas platyrhynchos
NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard
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