PANX2 protein (Anas platyrhynchos) - STRING interaction network

Nodes:

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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Score

PANX2

Pannexin; Structural component of the gap junctions and the hemichannels; Belongs to the pannexin family. (679 aa)

Predicted Functional Partners:

PANX1

0.674

GJC1

0.586

SLC18B1

0.489

GJA1

0.487

POMGNT2

0.487

GJB1

0.477

ARHGEF7

0.453

CALHM1

0.431

HOXC6

0.431

Your Current Organism:

Anas platyrhynchos

NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARHGEF7	PANX2	ENSAPLP00000031368	ENSAPLP00000002138	Rho guanine nucleotide exchange factor 7.	Pannexin; Structural component of the gap junctions and the hemichannels; Belongs to the pannexin family.	0.453
CALHM1	PANX1	ENSAPLP00000009792	ENSAPLP00000016061	Calcium homeostasis modulator 1.	Pannexin; Structural component of the gap junctions and the hemichannels.	0.507
CALHM1	PANX2	ENSAPLP00000009792	ENSAPLP00000002138	Calcium homeostasis modulator 1.	Pannexin; Structural component of the gap junctions and the hemichannels; Belongs to the pannexin family.	0.431
GJA1	GJB1	ENSAPLP00000000131	ENSAPLP00000000675	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	0.693
GJA1	GJC1	ENSAPLP00000000131	ENSAPLP00000001366	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	0.678
GJA1	PANX1	ENSAPLP00000000131	ENSAPLP00000016061	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	Pannexin; Structural component of the gap junctions and the hemichannels.	0.621
GJA1	PANX2	ENSAPLP00000000131	ENSAPLP00000002138	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	Pannexin; Structural component of the gap junctions and the hemichannels; Belongs to the pannexin family.	0.487
GJB1	GJA1	ENSAPLP00000000675	ENSAPLP00000000131	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	0.693
GJB1	GJC1	ENSAPLP00000000675	ENSAPLP00000001366	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	0.569
GJB1	PANX1	ENSAPLP00000000675	ENSAPLP00000016061	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	Pannexin; Structural component of the gap junctions and the hemichannels.	0.609
GJB1	PANX2	ENSAPLP00000000675	ENSAPLP00000002138	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	Pannexin; Structural component of the gap junctions and the hemichannels; Belongs to the pannexin family.	0.477
GJC1	GJA1	ENSAPLP00000001366	ENSAPLP00000000131	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	0.678
GJC1	GJB1	ENSAPLP00000001366	ENSAPLP00000000675	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	0.569
GJC1	PANX1	ENSAPLP00000001366	ENSAPLP00000016061	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	Pannexin; Structural component of the gap junctions and the hemichannels.	0.610
GJC1	PANX2	ENSAPLP00000001366	ENSAPLP00000002138	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	Pannexin; Structural component of the gap junctions and the hemichannels; Belongs to the pannexin family.	0.586
HOXC6	PANX2	ENSAPLP00000021358	ENSAPLP00000002138	Homeobox C6.	Pannexin; Structural component of the gap junctions and the hemichannels; Belongs to the pannexin family.	0.431
PANX1	CALHM1	ENSAPLP00000016061	ENSAPLP00000009792	Pannexin; Structural component of the gap junctions and the hemichannels.	Calcium homeostasis modulator 1.	0.507
PANX1	GJA1	ENSAPLP00000016061	ENSAPLP00000000131	Pannexin; Structural component of the gap junctions and the hemichannels.	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	0.621
PANX1	GJB1	ENSAPLP00000016061	ENSAPLP00000000675	Pannexin; Structural component of the gap junctions and the hemichannels.	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	0.609
PANX1	GJC1	ENSAPLP00000016061	ENSAPLP00000001366	Pannexin; Structural component of the gap junctions and the hemichannels.	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	0.610

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Network Stats

number of nodes:

11

number of edges:

28

average node degree:

5.09

avg. local clustering coefficient:

0.825

expected number of edges:

15

PPI enrichment p-value:

0.00198

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009432

SOS response

4 of 11

1.79

1.5

0.00075

GO:0006260

DNA replication

5 of 38

1.35

1.19

0.00083

GO:0006281

DNA repair

5 of 44

1.29

1.13

0.00083

GO:0006259

DNA metabolic process

7 of 128

0.97

0.83

0.00083

GO:0051301

Cell division

3 of 22

1.37

0.78

0.0179

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0015648

Lipid-linked peptidoglycan transporter activity

3 of 4

2.11

1.37

0.0024

GO:0003887

DNA-directed DNA polymerase activity

3 of 8

1.81

1.27

0.0027

GO:0140097

Catalytic activity, acting on DNA

5 of 73

1.07

0.83

0.0027

GO:0003684

Damaged DNA binding

2 of 6

1.76

0.73

0.0388

GO:0004252

Serine-type endopeptidase activity

2 of 8

1.63

0.67

0.0487

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:556

Mixed, incl. DNA replication, and Nucleotide excision repair

4 of 29

1.37

0.88

0.0096

CL:558

Mixed, incl. Nucleotide excision repair, and Mre11 nuclease, N-terminal metallophosphatase domain

3 of 18

1.46

0.75

0.0253

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03420

Nucleotide excision repair

3 of 14

1.56

0.96

0.0091

map03430

Mismatch repair

3 of 27

1.28

0.69

0.0261

map03440

Homologous recombination

3 of 31

1.22

0.67

0.0261

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0032153

Cell division site

3 of 5

2.01

1.43

0.0016

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0235

DNA replication

3 of 14

1.56

0.9

0.0130

KW-0239

DNA-directed DNA polymerase

2 of 5

1.84

0.88

0.0196

KW-0234

DNA repair

3 of 23

1.35

0.77

0.0181

KW-0227

DNA damage

3 of 23

1.35

0.77

0.0181

KW-0742

SOS response

2 of 8

1.63

0.73

0.0346

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF01098

Cell cycle protein

3 of 3

2.23

1.62

0.00083

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR001182

Probable peptidoglycan glycosyltransferase FtsW/RodA

3 of 3

2.23

1.39

0.0024

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