Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
MEGF10Multiple EGF like domains 10. (1044 aa)    
Predicted Functional Partners:
GULP1
GULP PTB domain containing engulfment adaptor 1.
   
 0.978
C1QB
Complement C1q B chain.
     
  0.901
C1QA
Complement C1q A chain.
     
  0.901
C1QC
Complement C1q C chain.
   
 
  0.901
MEGF11
Multiple EGF like domains 11.
  
  
 
0.900
AP2M1
AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...]
    
 
 0.702
GRIA2
Glutamate ionotropic receptor AMPA type subunit 2.
      
 0.662
IFT122
Intraflagellar transport 122.
      
 0.623
WSCD1
WSC domain containing 1.
    
 0.600
U3J0B3_ANAPP
Protein kinase domain-containing protein.
    
 0.599
Your Current Organism:
Anas platyrhynchos
NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard
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