MYOM3 protein (Anas platyrhynchos) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

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[Homology]

Score

MYOM3

Myomesin 3. (1429 aa)

Predicted Functional Partners:

TNNI1

0.625

MYOZ2

0.572

LMOD2

0.499

CSRP3

0.494

WDR18

0.422

Your Current Organism:

Anas platyrhynchos

NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CSRP3	LMOD2	ENSAPLP00000030170	ENSAPLP00000019661	Cysteine and glycine rich protein 3.	Leiomodin 2.	0.645
CSRP3	MYOM3	ENSAPLP00000030170	ENSAPLP00000003374	Cysteine and glycine rich protein 3.	Myomesin 3.	0.494
CSRP3	MYOZ2	ENSAPLP00000030170	ENSAPLP00000012486	Cysteine and glycine rich protein 3.	Myozenin 2.	0.891
CSRP3	TNNI1	ENSAPLP00000030170	ENSAPLP00000019947	Cysteine and glycine rich protein 3.	Troponin I1, slow skeletal type.	0.606
LMOD2	CSRP3	ENSAPLP00000019661	ENSAPLP00000030170	Leiomodin 2.	Cysteine and glycine rich protein 3.	0.645
LMOD2	MYOM3	ENSAPLP00000019661	ENSAPLP00000003374	Leiomodin 2.	Myomesin 3.	0.499
LMOD2	MYOZ2	ENSAPLP00000019661	ENSAPLP00000012486	Leiomodin 2.	Myozenin 2.	0.690
LMOD2	TNNI1	ENSAPLP00000019661	ENSAPLP00000019947	Leiomodin 2.	Troponin I1, slow skeletal type.	0.562
MYOM3	CSRP3	ENSAPLP00000003374	ENSAPLP00000030170	Myomesin 3.	Cysteine and glycine rich protein 3.	0.494
MYOM3	LMOD2	ENSAPLP00000003374	ENSAPLP00000019661	Myomesin 3.	Leiomodin 2.	0.499
MYOM3	MYOZ2	ENSAPLP00000003374	ENSAPLP00000012486	Myomesin 3.	Myozenin 2.	0.572
MYOM3	TNNI1	ENSAPLP00000003374	ENSAPLP00000019947	Myomesin 3.	Troponin I1, slow skeletal type.	0.625
MYOM3	WDR18	ENSAPLP00000003374	ENSAPLP00000006601	Myomesin 3.	WD repeat domain 18.	0.422
MYOZ2	CSRP3	ENSAPLP00000012486	ENSAPLP00000030170	Myozenin 2.	Cysteine and glycine rich protein 3.	0.891
MYOZ2	LMOD2	ENSAPLP00000012486	ENSAPLP00000019661	Myozenin 2.	Leiomodin 2.	0.690
MYOZ2	MYOM3	ENSAPLP00000012486	ENSAPLP00000003374	Myozenin 2.	Myomesin 3.	0.572
MYOZ2	TNNI1	ENSAPLP00000012486	ENSAPLP00000019947	Myozenin 2.	Troponin I1, slow skeletal type.	0.749
TNNI1	CSRP3	ENSAPLP00000019947	ENSAPLP00000030170	Troponin I1, slow skeletal type.	Cysteine and glycine rich protein 3.	0.606
TNNI1	LMOD2	ENSAPLP00000019947	ENSAPLP00000019661	Troponin I1, slow skeletal type.	Leiomodin 2.	0.562
TNNI1	MYOM3	ENSAPLP00000019947	ENSAPLP00000003374	Troponin I1, slow skeletal type.	Myomesin 3.	0.625

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

34

average node degree:

6.18

avg. local clustering coefficient:

0.841

expected number of edges:

16

PPI enrichment p-value:

3.86e-05

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000160

Phosphorelay signal transduction system

8 of 82

1.26

1.64

5.36e-07

GO:0007165

Signal transduction

9 of 122

1.14

1.4

5.36e-07

GO:0019538

Protein metabolic process

8 of 194

0.88

0.84

5.34e-05

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004673

Protein histidine kinase activity

7 of 39

1.52

2.26

1.94e-07

GO:0000155

Phosphorelay sensor kinase activity

6 of 35

1.5

2.0

2.21e-06

GO:0140096

Catalytic activity, acting on a protein

9 of 109

1.19

1.54

1.80e-07

GO:0016740

Transferase activity

8 of 304

0.69

0.54

0.0020

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2313

Phosphorelay signal transduction system, and GGDEF domain

6 of 72

1.19

1.17

0.00018

CL:2397

PAC motif, and Putative diguanylate phosphodiesterase

3 of 12

1.67

1.17

0.0034

CL:2309

Signal transduction, and Flagellar assembly

8 of 171

0.94

0.87

0.00018

CL:2400

Mixed, incl. PAS domain, and SsuA/THI5-like

2 of 6

1.79

0.78

0.0310

CL:2317

Phosphorelay signal transduction system

3 of 29

1.28

0.7

0.0250

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0418

Kinase

5 of 58

1.2

0.98

0.0019

KW-0597

Phosphoprotein

5 of 63

1.17

0.95

0.0019

KW-0175

Coiled coil

7 of 254

0.71

0.51

0.0070

KW-0808

Transferase

6 of 237

0.67

0.4

0.0359

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR004358

Signal transduction histidine kinase-related protein, C-terminal

7 of 29

1.65

2.73

2.51e-08

IPR003594

Histidine kinase/HSP90-like ATPase

8 of 40

1.57

2.65

6.63e-09

IPR036890

Histidine kinase/HSP90-like ATPase superfamily

8 of 41

1.56

2.62

6.63e-09

IPR005467

Histidine kinase domain

7 of 37

1.55

2.38

8.52e-08

IPR036097

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain superfamily

6 of 35

1.5

1.96

3.24e-06

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00387

Histidine kinase-like ATPases

8 of 39

1.58

2.89

4.69e-10

SM00388

His Kinase A (phosphoacceptor) domain

5 of 35

1.42

1.61

3.40e-05

SM00448

cheY-homologous receiver domain

5 of 55

1.23

1.21

0.00018

SM00091

PAS domain

3 of 21

1.42

1.03

0.0040

SM00086

Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)

3 of 21

1.42

1.03

0.0040

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