Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
IAPPIslet amyloid polypeptide. (135 aa)    
Predicted Functional Partners:
RAMP1
Receptor activity modifying protein 1.
     
 0.973
CALCR
Calcitonin receptor; Belongs to the G-protein coupled receptor 2 family.
     
 0.964
CALCRL
Calcitonin receptor like receptor; Belongs to the G-protein coupled receptor 2 family.
     
 0.958
ADM
Adrenomedullin.
     
 0.948
CALCB
Calcitonin related polypeptide beta.
     
 0.943
ADM2
Adrenomedullin 2.
     
 0.930
INS
Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
   
 
 0.745
SNCA
Alpha-synuclein; Belongs to the synuclein family.
    
 0.712
IDE
Insulin degrading enzyme; Belongs to the peptidase M16 family.
    
 
 0.659
RAMP2
Uncharacterized protein.
     
 0.631
Your Current Organism:
Anas platyrhynchos
NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard
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