STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
DERL2Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (156 aa)    
Predicted Functional Partners:
SEL1L
SEL1L adaptor subunit of ERAD E3 ubiquitin ligase.
   
 0.990
VCP
Valosin containing protein; Belongs to the AAA ATPase family.
   
 0.962
DERL1
Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.
   
 0.961
ERLEC1
Endoplasmic reticulum lectin 1.
   
 0.926
AMFR
Autocrine motility factor receptor.
   
 0.918
FAF2
Fas associated factor family member 2.
   
 
 0.917
SELENOS
Uncharacterized protein.
   
 0.903
EMC3
ER membrane protein complex subunit 3; Belongs to the EMC3 family.
   
 
 0.882
EMC2
ER membrane protein complex subunit 2.
    
 
 0.875
SEL1L3
SEL1L family member 3.
   
 0.818
Your Current Organism:
Anas platyrhynchos
NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.