| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| HMCES | LIG3 | ENSAPLP00000003568 | ENSAPLP00000008702 | Abasic site processing protein HMCES; Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA. The HMCES DNA-protein cross- link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endon [...] | DNA ligase. | 0.503 |
| HMCES | LYAR | ENSAPLP00000003568 | ENSAPLP00000002722 | Abasic site processing protein HMCES; Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA. The HMCES DNA-protein cross- link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endon [...] | Ly1 antibody reactive. | 0.611 |
| HMCES | OGFOD1 | ENSAPLP00000003568 | ENSAPLP00000012069 | Abasic site processing protein HMCES; Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA. The HMCES DNA-protein cross- link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endon [...] | 2-oxoglutarate and iron dependent oxygenase domain containing 1. | 0.626 |
| HMCES | RFWD3 | ENSAPLP00000003568 | ENSAPLP00000016048 | Abasic site processing protein HMCES; Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA. The HMCES DNA-protein cross- link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endon [...] | Ring finger and WD repeat domain 3. | 0.586 |
| HMCES | RIF1 | ENSAPLP00000003568 | ENSAPLP00000006751 | Abasic site processing protein HMCES; Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA. The HMCES DNA-protein cross- link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endon [...] | Replication timing regulatory factor 1. | 0.586 |
| HMCES | SHLD1 | ENSAPLP00000003568 | ENSAPLP00000028564 | Abasic site processing protein HMCES; Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA. The HMCES DNA-protein cross- link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endon [...] | Shieldin complex subunit 1. | 0.604 |
| HMCES | SHLD2 | ENSAPLP00000003568 | ENSAPLP00000013244 | Abasic site processing protein HMCES; Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA. The HMCES DNA-protein cross- link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endon [...] | Shieldin complex subunit 2. | 0.487 |
| HMCES | SMUG1 | ENSAPLP00000003568 | ENSAPLP00000029329 | Abasic site processing protein HMCES; Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA. The HMCES DNA-protein cross- link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endon [...] | Single-strand-selective monofunctional uracil-DNA glycosylase 1. | 0.478 |
| HMCES | SPRTN | ENSAPLP00000003568 | ENSAPLP00000013129 | Abasic site processing protein HMCES; Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA. The HMCES DNA-protein cross- link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endon [...] | SprT-like N-terminal domain. | 0.621 |
| HMCES | THYN1 | ENSAPLP00000003568 | ENSAPLP00000011790 | Abasic site processing protein HMCES; Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA. The HMCES DNA-protein cross- link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endon [...] | Thymocyte nuclear protein 1. | 0.485 |
| LIG3 | HMCES | ENSAPLP00000008702 | ENSAPLP00000003568 | DNA ligase. | Abasic site processing protein HMCES; Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA. The HMCES DNA-protein cross- link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endon [...] | 0.503 |
| LIG3 | RIF1 | ENSAPLP00000008702 | ENSAPLP00000006751 | DNA ligase. | Replication timing regulatory factor 1. | 0.483 |
| LIG3 | SHLD1 | ENSAPLP00000008702 | ENSAPLP00000028564 | DNA ligase. | Shieldin complex subunit 1. | 0.586 |
| LIG3 | SHLD2 | ENSAPLP00000008702 | ENSAPLP00000013244 | DNA ligase. | Shieldin complex subunit 2. | 0.586 |
| LYAR | HMCES | ENSAPLP00000002722 | ENSAPLP00000003568 | Ly1 antibody reactive. | Abasic site processing protein HMCES; Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA. The HMCES DNA-protein cross- link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endon [...] | 0.611 |
| LYAR | OGFOD1 | ENSAPLP00000002722 | ENSAPLP00000012069 | Ly1 antibody reactive. | 2-oxoglutarate and iron dependent oxygenase domain containing 1. | 0.657 |
| LYAR | THYN1 | ENSAPLP00000002722 | ENSAPLP00000011790 | Ly1 antibody reactive. | Thymocyte nuclear protein 1. | 0.590 |
| OGFOD1 | HMCES | ENSAPLP00000012069 | ENSAPLP00000003568 | 2-oxoglutarate and iron dependent oxygenase domain containing 1. | Abasic site processing protein HMCES; Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA. The HMCES DNA-protein cross- link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endon [...] | 0.626 |
| OGFOD1 | LYAR | ENSAPLP00000012069 | ENSAPLP00000002722 | 2-oxoglutarate and iron dependent oxygenase domain containing 1. | Ly1 antibody reactive. | 0.657 |
| OGFOD1 | THYN1 | ENSAPLP00000012069 | ENSAPLP00000011790 | 2-oxoglutarate and iron dependent oxygenase domain containing 1. | Thymocyte nuclear protein 1. | 0.609 |