STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
HMCESAbasic site processing protein HMCES; Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA. The HMCES DNA-protein cross- link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endon [...] (296 aa)    
Predicted Functional Partners:
OGFOD1
2-oxoglutarate and iron dependent oxygenase domain containing 1.
     
 0.626
SPRTN
SprT-like N-terminal domain.
      
 0.621
LYAR
Ly1 antibody reactive.
      
 0.611
SHLD1
Shieldin complex subunit 1.
      
 0.604
RIF1
Replication timing regulatory factor 1.
      
 0.586
RFWD3
Ring finger and WD repeat domain 3.
      
 0.586
LIG3
DNA ligase.
     
 0.503
SHLD2
Shieldin complex subunit 2.
      
 0.487
THYN1
Thymocyte nuclear protein 1.
      
 0.485
SMUG1
Single-strand-selective monofunctional uracil-DNA glycosylase 1.
     
 0.478
Your Current Organism:
Anas platyrhynchos
NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard
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