Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
MAPK12Mitogen-activated protein kinase. (361 aa)    
Predicted Functional Partners:
PTPN3
Tyrosine-protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily.
    
 0.989
MAPKAPK2
MAPK activated protein kinase 2.
  
0.988
MAPKAPK3
MAPK activated protein kinase 3; Belongs to the protein kinase superfamily.
  
0.984
MAP2K3
Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily.
  
0.977
MAP2K6
Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily.
  
0.977
MEF2C
Myocyte enhancer factor 2C.
    
 0.970
JUN
Jun proto-oncogene, AP-1 transcription factor subunit.
    
 0.970
ATF2
Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family.
    
 0.968
U3ILW2_ANAPP
Protein kinase domain-containing protein.
   
0.965
CDC42
Cell division cycle 42.
   
 0.957
Your Current Organism:
Anas platyrhynchos
NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard
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