KLF5 protein (Anas platyrhynchos) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

KLF5

Kruppel like factor 5. (446 aa)

Predicted Functional Partners:

CEBPB

0.697

WWP1

0.619

PIBF1

0.612

PPARG

0.609

CEBPD

0.593

HDAC1

0.538

EP300

0.508

MYOZ2

0.497

ESRRB

0.496

CEBPA

0.450

Your Current Organism:

Anas platyrhynchos

NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CEBPA	CEBPB	ENSAPLP00000031202	ENSAPLP00000021900	CCAAT enhancer binding protein alpha.	CCAAT/enhancer-binding protein.	0.767
CEBPA	EP300	ENSAPLP00000031202	ENSAPLP00000010252	CCAAT enhancer binding protein alpha.	E1A binding protein p300.	0.412
CEBPA	KLF5	ENSAPLP00000031202	ENSAPLP00000003830	CCAAT enhancer binding protein alpha.	Kruppel like factor 5.	0.450
CEBPA	PPARG	ENSAPLP00000031202	ENSAPLP00000008758	CCAAT enhancer binding protein alpha.	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	0.766
CEBPB	CEBPA	ENSAPLP00000021900	ENSAPLP00000031202	CCAAT/enhancer-binding protein.	CCAAT enhancer binding protein alpha.	0.767
CEBPB	CEBPD	ENSAPLP00000021900	ENSAPLP00000017410	CCAAT/enhancer-binding protein.	CCAAT enhancer binding protein delta.	0.728
CEBPB	EP300	ENSAPLP00000021900	ENSAPLP00000010252	CCAAT/enhancer-binding protein.	E1A binding protein p300.	0.778
CEBPB	KLF5	ENSAPLP00000021900	ENSAPLP00000003830	CCAAT/enhancer-binding protein.	Kruppel like factor 5.	0.697
CEBPB	PPARG	ENSAPLP00000021900	ENSAPLP00000008758	CCAAT/enhancer-binding protein.	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	0.882
CEBPD	CEBPB	ENSAPLP00000017410	ENSAPLP00000021900	CCAAT enhancer binding protein delta.	CCAAT/enhancer-binding protein.	0.728
CEBPD	KLF5	ENSAPLP00000017410	ENSAPLP00000003830	CCAAT enhancer binding protein delta.	Kruppel like factor 5.	0.593
CEBPD	PPARG	ENSAPLP00000017410	ENSAPLP00000008758	CCAAT enhancer binding protein delta.	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	0.681
EP300	CEBPA	ENSAPLP00000010252	ENSAPLP00000031202	E1A binding protein p300.	CCAAT enhancer binding protein alpha.	0.412
EP300	CEBPB	ENSAPLP00000010252	ENSAPLP00000021900	E1A binding protein p300.	CCAAT/enhancer-binding protein.	0.778
EP300	HDAC1	ENSAPLP00000010252	ENSAPLP00000019850	E1A binding protein p300.	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.646
EP300	KLF5	ENSAPLP00000010252	ENSAPLP00000003830	E1A binding protein p300.	Kruppel like factor 5.	0.508
EP300	PPARG	ENSAPLP00000010252	ENSAPLP00000008758	E1A binding protein p300.	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	0.865
ESRRB	KLF5	ENSAPLP00000022940	ENSAPLP00000003830	Estrogen related receptor beta.	Kruppel like factor 5.	0.496
HDAC1	EP300	ENSAPLP00000019850	ENSAPLP00000010252	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	E1A binding protein p300.	0.646
HDAC1	KLF5	ENSAPLP00000019850	ENSAPLP00000003830	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	Kruppel like factor 5.	0.538