Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
MCM2DNA helicase; Belongs to the MCM family. (889 aa)    
Predicted Functional Partners:
MCM4
DNA helicase; Belongs to the MCM family.
   
0.999
MCM5
DNA helicase; Belongs to the MCM family.
   
0.999
MCM3
DNA helicase; Belongs to the MCM family.
   
0.999
MCM6
DNA helicase; Belongs to the MCM family.
   
0.999
CDT1
Chromatin licensing and DNA replication factor 1.
   
 0.997
ORC1
Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.
  
 0.996
CDC45
Cell division cycle 45.
   
 0.996
ORC5
Origin recognition complex subunit 5.
   
 0.991
DBF4
DBF4 zinc finger.
   
 0.990
POLA1
DNA polymerase.
   
 0.990
Your Current Organism:
Anas platyrhynchos
NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard
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