Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
TRHDEThyrotropin releasing hormone degrading enzyme. (1045 aa)    
Predicted Functional Partners:
TRH
Pro-thyrotropin-releasing hormone; Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems.
      
 0.737
AGT
Angiotensinogen; Belongs to the serpin family.
   
 0.615
NR3C1
Nuclear receptor subfamily 3 group C member 1.
      
 0.553
PRLR
Prolactin receptor; This is a receptor for the anterior pituitary hormone prolactin; Belongs to the type I cytokine receptor family. Type 1 subfamily.
      
 0.545
HSPA5
Heat shock protein family A (Hsp70) member 5; Belongs to the heat shock protein 70 family.
    
 0.515
CLN5
Uncharacterized protein.
      
 0.514
CAMKMT
Calmodulin-lysine N-methyltransferase.
    
 
 0.504
RFXANK
ANK_REP_REGION domain-containing protein.
    
 
 0.487
THRB
Thyroid hormone receptor beta.
   
  
 0.463
THRA
Thyroid hormone receptor alpha.
   
  
 0.463
Your Current Organism:
Anas platyrhynchos
NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard
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