STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PDCD1LG2Uncharacterized protein. (321 aa)    
Predicted Functional Partners:
PDCD1
Ig-like domain-containing protein.
   
 0.999
CD274
Uncharacterized protein.
   
 0.929
CD4
Ig-like domain-containing protein.
   
 
 0.770
CTLA4
Cytotoxic T-lymphocyte associated protein 4.
   
 
 0.704
LAG3
Lymphocyte activating 3.
   
 
 0.695
IFNG
Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.
   
  
 0.673
VTCN1
V-set domain containing T cell activation inhibitor 1.
      
 0.659
CD86
CD86 molecule.
   
  
 0.649
CORIN
Corin, serine peptidase.
     
 0.649
CD3E
CD3e molecule.
     
 0.646
Your Current Organism:
Anas platyrhynchos
NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard
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