VCP protein (Anas platyrhynchos) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

VCP

Valosin containing protein; Belongs to the AAA ATPase family. (855 aa)

Predicted Functional Partners:

NSFL1C

0.998

UBXN2A

0.996

UFD1

0.996

ENSAPLP00000030396

0.995

DERL1

0.994

YOD1

0.992

VCPKMT

0.992

UBXN7

0.991

UBXN4

0.989

FAF2

0.988

Your Current Organism:

Anas platyrhynchos

NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DERL1	ENSAPLP00000030396	ENSAPLP00000025861	ENSAPLP00000030396	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Uncharacterized protein.	0.730
DERL1	FAF2	ENSAPLP00000025861	ENSAPLP00000009133	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Fas associated factor family member 2.	0.961
DERL1	NSFL1C	ENSAPLP00000025861	ENSAPLP00000011000	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	NSFL1 cofactor.	0.761
DERL1	UBXN2A	ENSAPLP00000025861	ENSAPLP00000012516	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	UBX domain protein 2A.	0.554
DERL1	UFD1	ENSAPLP00000025861	ENSAPLP00000019196	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Ubiquitin recognition factor in ER associated degradation 1.	0.895
DERL1	VCP	ENSAPLP00000025861	ENSAPLP00000004138	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Valosin containing protein; Belongs to the AAA ATPase family.	0.994
ENSAPLP00000030396	DERL1	ENSAPLP00000030396	ENSAPLP00000025861	Uncharacterized protein.	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	0.730
ENSAPLP00000030396	NSFL1C	ENSAPLP00000030396	ENSAPLP00000011000	Uncharacterized protein.	NSFL1 cofactor.	0.915
ENSAPLP00000030396	UBXN2A	ENSAPLP00000030396	ENSAPLP00000012516	Uncharacterized protein.	UBX domain protein 2A.	0.942
ENSAPLP00000030396	UBXN4	ENSAPLP00000030396	ENSAPLP00000024914	Uncharacterized protein.	Uncharacterized protein.	0.902
ENSAPLP00000030396	UFD1	ENSAPLP00000030396	ENSAPLP00000019196	Uncharacterized protein.	Ubiquitin recognition factor in ER associated degradation 1.	0.402
ENSAPLP00000030396	VCP	ENSAPLP00000030396	ENSAPLP00000004138	Uncharacterized protein.	Valosin containing protein; Belongs to the AAA ATPase family.	0.995
FAF2	DERL1	ENSAPLP00000009133	ENSAPLP00000025861	Fas associated factor family member 2.	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	0.961
FAF2	NSFL1C	ENSAPLP00000009133	ENSAPLP00000011000	Fas associated factor family member 2.	NSFL1 cofactor.	0.526
FAF2	UBXN2A	ENSAPLP00000009133	ENSAPLP00000012516	Fas associated factor family member 2.	UBX domain protein 2A.	0.600
FAF2	UBXN7	ENSAPLP00000009133	ENSAPLP00000024434	Fas associated factor family member 2.	UBX domain-containing protein 7.	0.981
FAF2	UFD1	ENSAPLP00000009133	ENSAPLP00000019196	Fas associated factor family member 2.	Ubiquitin recognition factor in ER associated degradation 1.	0.981
FAF2	VCP	ENSAPLP00000009133	ENSAPLP00000004138	Fas associated factor family member 2.	Valosin containing protein; Belongs to the AAA ATPase family.	0.988
FAF2	YOD1	ENSAPLP00000009133	ENSAPLP00000001266	Fas associated factor family member 2.	YOD1 deubiquitinase.	0.413
NSFL1C	DERL1	ENSAPLP00000011000	ENSAPLP00000025861	NSFL1 cofactor.	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	0.761