PMS2 protein (Anas platyrhynchos) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

PMS2

PMS1 homolog 2, mismatch repair system component. (867 aa)

Predicted Functional Partners:

MLH1

0.999

MSH6

0.998

MSH3

0.993

MSH2

0.993

EXO1

0.977

FAN1

0.963

BRIP1

0.946

PCNA

0.895

MSH4

0.894

MSH5

0.862

Your Current Organism:

Anas platyrhynchos

NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BRIP1	EXO1	ENSAPLP00000008824	ENSAPLP00000014890	Helicase ATP-binding domain-containing protein.	Exonuclease 1.	0.828
BRIP1	MLH1	ENSAPLP00000008824	ENSAPLP00000025394	Helicase ATP-binding domain-containing protein.	MutL homolog 1.	0.978
BRIP1	PCNA	ENSAPLP00000008824	ENSAPLP00000028238	Helicase ATP-binding domain-containing protein.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.535
BRIP1	PMS2	ENSAPLP00000008824	ENSAPLP00000004148	Helicase ATP-binding domain-containing protein.	PMS1 homolog 2, mismatch repair system component.	0.946
EXO1	BRIP1	ENSAPLP00000014890	ENSAPLP00000008824	Exonuclease 1.	Helicase ATP-binding domain-containing protein.	0.828
EXO1	MLH1	ENSAPLP00000014890	ENSAPLP00000025394	Exonuclease 1.	MutL homolog 1.	0.981
EXO1	MSH2	ENSAPLP00000014890	ENSAPLP00000015286	Exonuclease 1.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.977
EXO1	MSH3	ENSAPLP00000014890	ENSAPLP00000006745	Exonuclease 1.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.889
EXO1	MSH4	ENSAPLP00000014890	ENSAPLP00000014123	Exonuclease 1.	MutS homolog 4.	0.784
EXO1	MSH5	ENSAPLP00000014890	ENSAPLP00000000362	Exonuclease 1.	DNA_MISMATCH_REPAIR_2 domain-containing protein.	0.772
EXO1	MSH6	ENSAPLP00000014890	ENSAPLP00000015904	Exonuclease 1.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.988
EXO1	PCNA	ENSAPLP00000014890	ENSAPLP00000028238	Exonuclease 1.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.963
EXO1	PMS2	ENSAPLP00000014890	ENSAPLP00000004148	Exonuclease 1.	PMS1 homolog 2, mismatch repair system component.	0.977
FAN1	MLH1	ENSAPLP00000006932	ENSAPLP00000025394	Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family.	MutL homolog 1.	0.977
FAN1	MSH2	ENSAPLP00000006932	ENSAPLP00000015286	Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.441
FAN1	PMS2	ENSAPLP00000006932	ENSAPLP00000004148	Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family.	PMS1 homolog 2, mismatch repair system component.	0.963
MLH1	BRIP1	ENSAPLP00000025394	ENSAPLP00000008824	MutL homolog 1.	Helicase ATP-binding domain-containing protein.	0.978
MLH1	EXO1	ENSAPLP00000025394	ENSAPLP00000014890	MutL homolog 1.	Exonuclease 1.	0.981
MLH1	FAN1	ENSAPLP00000025394	ENSAPLP00000006932	MutL homolog 1.	Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family.	0.977
MLH1	MSH2	ENSAPLP00000025394	ENSAPLP00000015286	MutL homolog 1.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.998