Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
PCSK9Proprotein convertase subtilisin/kexin type 9; Belongs to the peptidase S8 family. (656 aa)    
Predicted Functional Partners:
APOB
Apolipoprotein B.
   
  
 0.905
LRP8
LDL receptor related protein 8.
    
 0.889
U3J7G1_ANAPP
Uncharacterized protein.
    
 0.888
ENSAPLP00000016508
Uncharacterized protein.
    
 0.888
PCSK1
Proprotein convertase subtilisin/kexin type 1; Belongs to the peptidase S8 family.
      
 0.871
PCSK2
Proprotein convertase subtilisin/kexin type 2; Belongs to the peptidase S8 family.
      
 0.871
EGF
Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.
    
 0.797
FAM20C
FAM20C golgi associated secretory pathway kinase.
    
 0.753
ENSAPLP00000028354
Uncharacterized protein.
    
 0.753
PI4KA
Phosphatidylinositol 4-kinase alpha; Belongs to the PI3/PI4-kinase family.
    
 
 0.727
Your Current Organism:
Anas platyrhynchos
NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard
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