STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
NOTCH1Uncharacterized protein. (2250 aa)    
Predicted Functional Partners:
JAG1
Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.
   
0.999
JAG2
Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.
   
0.998
DLL1
Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.
   
0.997
RBPJ
Recombination signal binding protein for immunoglobulin kappa J region.
    
 0.996
DLL4
Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.
   
0.986
PSEN1
Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.
    
 0.980
PSEN2
Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.
    
 0.963
NUMB
NUMB endocytic adaptor protein.
    
 0.960
RBPJL
Recombination signal binding protein for immunoglobulin kappa J region like.
    
 0.946
ADAM17
ADAM metallopeptidase domain 17.
    
 0.940
Your Current Organism:
Anas platyrhynchos
NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard
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