METAP2 protein (Anas platyrhynchos) - STRING interaction network

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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gene co-occurrence

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METAP2

Methionine aminopeptidase 2; Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met- Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily. (482 aa)

Predicted Functional Partners:

METAP1

0.930

RPL35

0.924

FAU

0.923

RPL5

0.922

RPS3

0.909

RPL23

0.905

DEGS2

0.896

DEGS1

0.896

RPL26

0.886

RPS11

0.884

Your Current Organism:

Anas platyrhynchos

NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DEGS1	DEGS2	ENSAPLP00000012405	ENSAPLP00000003095	Delta 4-desaturase, sphingolipid 1.	Delta 4-desaturase, sphingolipid 2.	0.901
DEGS1	METAP2	ENSAPLP00000012405	ENSAPLP00000004311	Delta 4-desaturase, sphingolipid 1.	Methionine aminopeptidase 2; Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met- Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.	0.896
DEGS2	DEGS1	ENSAPLP00000003095	ENSAPLP00000012405	Delta 4-desaturase, sphingolipid 2.	Delta 4-desaturase, sphingolipid 1.	0.901
DEGS2	METAP2	ENSAPLP00000003095	ENSAPLP00000004311	Delta 4-desaturase, sphingolipid 2.	Methionine aminopeptidase 2; Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met- Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.	0.896
FAU	METAP1	ENSAPLP00000027823	ENSAPLP00000015627	40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family.	Methionine aminopeptidase; Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met- Ala-, Cys, Gly, Pro, Ser, Thr, or Val).	0.923
FAU	METAP2	ENSAPLP00000027823	ENSAPLP00000004311	40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family.	Methionine aminopeptidase 2; Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met- Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.	0.923
FAU	RPL23	ENSAPLP00000027823	ENSAPLP00000010466	40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family.	Ribosomal protein L23; Belongs to the universal ribosomal protein uL14 family.	0.998
FAU	RPL26	ENSAPLP00000027823	ENSAPLP00000015238	40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family.	Ribosomal protein L26.	0.998
FAU	RPL35	ENSAPLP00000027823	ENSAPLP00000003880	40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family.	Ribosomal protein L35.	0.997
FAU	RPL5	ENSAPLP00000027823	ENSAPLP00000015871	40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family.	Ribosomal_L18_c domain-containing protein.	0.998
FAU	RPS11	ENSAPLP00000027823	ENSAPLP00000028396	40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family.	Ribosomal protein S11.	0.999
FAU	RPS3	ENSAPLP00000027823	ENSAPLP00000014372	40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family.	KH type-2 domain-containing protein; Belongs to the universal ribosomal protein uS3 family.	0.999
METAP1	FAU	ENSAPLP00000015627	ENSAPLP00000027823	Methionine aminopeptidase; Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met- Ala-, Cys, Gly, Pro, Ser, Thr, or Val).	40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family.	0.923
METAP1	METAP2	ENSAPLP00000015627	ENSAPLP00000004311	Methionine aminopeptidase; Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met- Ala-, Cys, Gly, Pro, Ser, Thr, or Val).	Methionine aminopeptidase 2; Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met- Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.	0.930
METAP1	RPL23	ENSAPLP00000015627	ENSAPLP00000010466	Methionine aminopeptidase; Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met- Ala-, Cys, Gly, Pro, Ser, Thr, or Val).	Ribosomal protein L23; Belongs to the universal ribosomal protein uL14 family.	0.905
METAP1	RPL26	ENSAPLP00000015627	ENSAPLP00000015238	Methionine aminopeptidase; Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met- Ala-, Cys, Gly, Pro, Ser, Thr, or Val).	Ribosomal protein L26.	0.886
METAP1	RPL35	ENSAPLP00000015627	ENSAPLP00000003880	Methionine aminopeptidase; Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met- Ala-, Cys, Gly, Pro, Ser, Thr, or Val).	Ribosomal protein L35.	0.924
METAP1	RPL5	ENSAPLP00000015627	ENSAPLP00000015871	Methionine aminopeptidase; Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met- Ala-, Cys, Gly, Pro, Ser, Thr, or Val).	Ribosomal_L18_c domain-containing protein.	0.922
METAP1	RPS11	ENSAPLP00000015627	ENSAPLP00000028396	Methionine aminopeptidase; Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met- Ala-, Cys, Gly, Pro, Ser, Thr, or Val).	Ribosomal protein S11.	0.884
METAP1	RPS3	ENSAPLP00000015627	ENSAPLP00000014372	Methionine aminopeptidase; Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met- Ala-, Cys, Gly, Pro, Ser, Thr, or Val).	KH type-2 domain-containing protein; Belongs to the universal ribosomal protein uS3 family.	0.909

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Network Stats

number of nodes:

11

number of edges:

49

average node degree:

8.91

avg. local clustering coefficient:

0.927

expected number of edges:

10

PPI enrichment p-value:

< 1.0e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006412

Translation

10 of 349

1.77

4.26

7.07e-14

GO:0002181

Cytoplasmic translation

3 of 47

2.12

1.61

0.00077

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003735

Structural constituent of ribosome

9 of 165

2.05

5.56

1.01e-14

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005840

Ribosome

10 of 192

2.03

6.14

3.18e-17

GO:0022626

Cytosolic ribosome

5 of 56

2.27

3.69

3.28e-08

GO:0022625

Cytosolic large ribosomal subunit

4 of 34

2.39

3.12

8.90e-07

GO:0044391

Ribosomal subunit

5 of 143

1.86

2.57

1.50e-06

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:360

Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)

9 of 64

2.47

8.07

5.64e-18

CL:368

Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)

8 of 54

2.49

7.58

1.36e-16

CL:370

Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)

7 of 43

2.53

6.85

1.20e-14

CL:295

Formation of a pool of free 40S subunits, and Delayed rectifier potassium channel activity

10 of 190

2.04

6.2

2.28e-17

CL:372

Cytosolic large ribosomal subunit, and Ribosomal protein L13

4 of 18

2.66

3.88

4.79e-08

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

pret03010

Ribosome

10 of 113

2.26

8.1

2.54e-20

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-975956

Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)

9 of 107

2.24

6.81

1.47e-16

MAP-72689

Formation of a pool of free 40S subunits

9 of 112

2.22

6.74

1.47e-16

MAP-1799339

SRP-dependent cotranslational protein targeting to membrane

9 of 119

2.2

6.64

1.47e-16

MAP-72706

GTP hydrolysis and joining of the 60S ribosomal subunit

9 of 121

2.19

6.61

1.47e-16

MAP-156827

L13a-mediated translational silencing of Ceruloplasmin expression

9 of 129

2.16

6.51

1.48e-16

(more ...)

Tissue Expression (TISSUES)

tissue

description

count in network

strength

signal

false discovery rate

BTO:0001489

Whole body

11 of 13032

0.24

0.23

0.0187

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0022626

Cytosolic ribosome

9 of 55

2.53

8.69

4.91e-19

GOCC:0015934

Large ribosomal subunit

7 of 66

2.34

5.88

3.14e-13

GOCC:0044391

Ribosomal subunit

8 of 121

2.14

5.59

6.83e-14

GOCC:0022625

Cytosolic large ribosomal subunit

5 of 16

2.81

5.48

4.59e-11

GOCC:0042788

Polysomal ribosome

4 of 21

2.6

3.77

6.98e-08

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0689

Ribosomal protein

4 of 59

2.15

2.61

5.68e-06

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