Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
CASP2Caspase 2; Belongs to the peptidase C14A family. (426 aa)    
Predicted Functional Partners:
PIDD1
P53-induced death domain protein 1.
    
 0.995
CRADD
CASP2 and RIPK1 domain containing adaptor with death domain.
    
 0.988
BID
BH3-interacting domain death agonist; Counters the protective effect of Bcl-2.
   
 0.967
APAF1
Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.
    
 0.870
U3HZQ3_ANAPP
Uncharacterized protein; Belongs to the peptidase C14A family.
    
 0.839
CASP3
Caspase 3; Belongs to the peptidase C14A family.
    
 0.839
XIAP
X-linked inhibitor of apoptosis.
   
 0.767
U3ITT3_ANAPP
Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
   
 0.765
ENSAPLP00000030826
Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
   
 0.765
U3J6D9_ANAPP
Uncharacterized protein; Belongs to the peptidase C14A family.
   
0.696
Your Current Organism:
Anas platyrhynchos
NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard
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