| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| APAF1 | AVEN | ENSAPLP00000010171 | ENSAPLP00000004654 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | Apoptosis and caspase activation inhibitor. | 0.848 |
| APAF1 | CASP9 | ENSAPLP00000010171 | ENSAPLP00000008534 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | Caspase 9; Belongs to the peptidase C14A family. | 0.999 |
| APAF1 | ENSAPLP00000030826 | ENSAPLP00000010171 | ENSAPLP00000030826 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. | 0.997 |
| APAF1 | MCL1 | ENSAPLP00000010171 | ENSAPLP00000031320 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | MCL1 apoptosis regulator, BCL2 family member. | 0.838 |
| APAF1 | U3ITT3_ANAPP | ENSAPLP00000010171 | ENSAPLP00000010656 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. | 0.979 |
| AVEN | APAF1 | ENSAPLP00000004654 | ENSAPLP00000010171 | Apoptosis and caspase activation inhibitor. | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | 0.848 |
| AVEN | BPHL | ENSAPLP00000004654 | ENSAPLP00000015407 | Apoptosis and caspase activation inhibitor. | Biphenyl hydrolase like. | 0.479 |
| AVEN | CASP9 | ENSAPLP00000004654 | ENSAPLP00000008534 | Apoptosis and caspase activation inhibitor. | Caspase 9; Belongs to the peptidase C14A family. | 0.533 |
| AVEN | ENSAPLP00000030826 | ENSAPLP00000004654 | ENSAPLP00000030826 | Apoptosis and caspase activation inhibitor. | Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. | 0.621 |
| AVEN | FOCAD | ENSAPLP00000004654 | ENSAPLP00000020604 | Apoptosis and caspase activation inhibitor. | Focadhesin. | 0.887 |
| AVEN | MCL1 | ENSAPLP00000004654 | ENSAPLP00000031320 | Apoptosis and caspase activation inhibitor. | MCL1 apoptosis regulator, BCL2 family member. | 0.493 |
| AVEN | PPP4R4 | ENSAPLP00000004654 | ENSAPLP00000011141 | Apoptosis and caspase activation inhibitor. | Protein phosphatase 4 regulatory subunit 4. | 0.479 |
| AVEN | U3IG51_ANAPP | ENSAPLP00000004654 | ENSAPLP00000006223 | Apoptosis and caspase activation inhibitor. | Cystatin domain-containing protein. | 0.462 |
| AVEN | U3ITT3_ANAPP | ENSAPLP00000004654 | ENSAPLP00000010656 | Apoptosis and caspase activation inhibitor. | Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. | 0.621 |
| AVEN | UBFD1 | ENSAPLP00000004654 | ENSAPLP00000016904 | Apoptosis and caspase activation inhibitor. | Ubiquitin family domain containing 1. | 0.479 |
| BPHL | AVEN | ENSAPLP00000015407 | ENSAPLP00000004654 | Biphenyl hydrolase like. | Apoptosis and caspase activation inhibitor. | 0.479 |
| BPHL | PPP4R4 | ENSAPLP00000015407 | ENSAPLP00000011141 | Biphenyl hydrolase like. | Protein phosphatase 4 regulatory subunit 4. | 0.623 |
| BPHL | UBFD1 | ENSAPLP00000015407 | ENSAPLP00000016904 | Biphenyl hydrolase like. | Ubiquitin family domain containing 1. | 0.546 |
| CASP9 | APAF1 | ENSAPLP00000008534 | ENSAPLP00000010171 | Caspase 9; Belongs to the peptidase C14A family. | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | 0.999 |
| CASP9 | AVEN | ENSAPLP00000008534 | ENSAPLP00000004654 | Caspase 9; Belongs to the peptidase C14A family. | Apoptosis and caspase activation inhibitor. | 0.533 |