AHSA2P protein (Anas platyrhynchos) - STRING interaction network

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second shell of interactors

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Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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Score

AHSA2P

Aha1_N domain-containing protein. (324 aa)

Predicted Functional Partners:

PTGES3

0.752

HSP90B1

0.749

PPIG

0.735

PPID

0.735

NKTR

0.735

HSPA4

0.728

HSPA4L

0.728

HSP90AA1

0.717

ENSAPLP00000021501

0.717

ENSAPLP00000025272

0.717

Your Current Organism:

Anas platyrhynchos

NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AHSA2P	ENSAPLP00000021501	ENSAPLP00000005060	ENSAPLP00000021501	Aha1_N domain-containing protein.	HATPase_c domain-containing protein.	0.717
AHSA2P	ENSAPLP00000025272	ENSAPLP00000005060	ENSAPLP00000025272	Aha1_N domain-containing protein.	Uncharacterized protein.	0.717
AHSA2P	HSP90AA1	ENSAPLP00000005060	ENSAPLP00000017253	Aha1_N domain-containing protein.	Uncharacterized protein.	0.717
AHSA2P	HSP90B1	ENSAPLP00000005060	ENSAPLP00000019318	Aha1_N domain-containing protein.	Heat shock protein 90 beta family member 1.	0.749
AHSA2P	HSPA4	ENSAPLP00000005060	ENSAPLP00000002168	Aha1_N domain-containing protein.	Heat shock protein family A (Hsp70) member 4.	0.728
AHSA2P	HSPA4L	ENSAPLP00000005060	ENSAPLP00000007920	Aha1_N domain-containing protein.	Heat shock protein family A (Hsp70) member 4 like.	0.728
AHSA2P	NKTR	ENSAPLP00000005060	ENSAPLP00000028754	Aha1_N domain-containing protein.	Natural killer cell triggering receptor.	0.735
AHSA2P	PPID	ENSAPLP00000005060	ENSAPLP00000014598	Aha1_N domain-containing protein.	Peptidylprolyl isomerase D.	0.735
AHSA2P	PPIG	ENSAPLP00000005060	ENSAPLP00000006016	Aha1_N domain-containing protein.	Peptidylprolyl isomerase G.	0.735
AHSA2P	PTGES3	ENSAPLP00000005060	ENSAPLP00000028684	Aha1_N domain-containing protein.	Prostaglandin E synthase 3.	0.752
ENSAPLP00000021501	AHSA2P	ENSAPLP00000021501	ENSAPLP00000005060	HATPase_c domain-containing protein.	Aha1_N domain-containing protein.	0.717
ENSAPLP00000021501	ENSAPLP00000025272	ENSAPLP00000021501	ENSAPLP00000025272	HATPase_c domain-containing protein.	Uncharacterized protein.	0.951
ENSAPLP00000021501	HSP90AA1	ENSAPLP00000021501	ENSAPLP00000017253	HATPase_c domain-containing protein.	Uncharacterized protein.	0.951
ENSAPLP00000021501	HSPA4	ENSAPLP00000021501	ENSAPLP00000002168	HATPase_c domain-containing protein.	Heat shock protein family A (Hsp70) member 4.	0.678
ENSAPLP00000021501	HSPA4L	ENSAPLP00000021501	ENSAPLP00000007920	HATPase_c domain-containing protein.	Heat shock protein family A (Hsp70) member 4 like.	0.622
ENSAPLP00000021501	NKTR	ENSAPLP00000021501	ENSAPLP00000028754	HATPase_c domain-containing protein.	Natural killer cell triggering receptor.	0.706
ENSAPLP00000021501	PPID	ENSAPLP00000021501	ENSAPLP00000014598	HATPase_c domain-containing protein.	Peptidylprolyl isomerase D.	0.774
ENSAPLP00000021501	PPIG	ENSAPLP00000021501	ENSAPLP00000006016	HATPase_c domain-containing protein.	Peptidylprolyl isomerase G.	0.706
ENSAPLP00000021501	PTGES3	ENSAPLP00000021501	ENSAPLP00000028684	HATPase_c domain-containing protein.	Prostaglandin E synthase 3.	0.910
ENSAPLP00000025272	AHSA2P	ENSAPLP00000025272	ENSAPLP00000005060	Uncharacterized protein.	Aha1_N domain-containing protein.	0.717

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

14

average node degree:

2.55

avg. local clustering coefficient:

0.887

expected number of edges:

10

PPI enrichment p-value:

0.144

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0044772

Mitotic cell cycle phase transition

6 of 120

1.96

3.11

1.08e-07

GO:1905786

Positive regulation of anaphase-promoting complex-dependent catabolic process

3 of 3

3.26

3.06

2.90e-06

GO:0031145

Anaphase-promoting complex-dependent catabolic process

3 of 19

2.46

2.18

8.35e-05

GO:0000079

Regulation of cyclin-dependent protein serine/threonine kinase activity

4 of 73

2.0

2.16

3.82e-05

GO:0031396

Regulation of protein ubiquitination

5 of 171

1.73

2.06

1.76e-05

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:1990757

Ubiquitin ligase activator activity

3 of 4

3.14

2.7

1.26e-05

GO:0010997

Anaphase-promoting complex binding

3 of 9

2.79

2.56

1.98e-05

GO:0016538

Cyclin-dependent protein serine/threonine kinase regulator activity

4 of 51

2.16

2.4

1.70e-05

GO:0043125

ErbB-3 class receptor binding

2 of 4

2.96

1.63

0.0011

GO:0030549

Acetylcholine receptor activator activity

2 of 4

2.96

1.63

0.0011

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000307

Cyclin-dependent protein kinase holoenzyme complex

6 of 51

2.33

4.66

2.70e-10

GO:0005680

Anaphase-promoting complex

3 of 21

2.42

2.26

5.31e-05

GO:1990234

Transferase complex

9 of 815

1.31

1.96

7.84e-09

GO:0016533

Protein kinase 5 complex

2 of 4

2.96

1.77

0.00062

GO:0031461

cullin-RING ubiquitin ligase complex

4 of 177

1.62

1.51

0.00037

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:8864

Cell cycle, and Regulation of APC/C activators between G1/S and early anaphase

4 of 77

1.98

1.72

0.00035

CL:8865

Cell cycle, and Regulation of APC/C activators between G1/S and early anaphase

3 of 69

1.9

0.94

0.0158

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

CFA-176417

Phosphorylation of Emi1

2 of 7

2.72

1.12

0.0094

CFA-174113

SCF-beta-TrCP mediated degradation of Emi1

2 of 8

2.66

1.12

0.0094

CFA-69656

Cyclin A:Cdk2-associated events at S phase entry

3 of 65

1.93

1.05

0.0094

CFA-176407

Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase

2 of 20

2.26

0.9

0.0220

CFA-69231

Cyclin D associated events in G1

2 of 38

1.99

0.76

0.0370

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0195

Cyclin

3 of 34

2.21

1.79

0.00038

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00385

Domain present in cyclins, TFIIB and Retinoblastoma

3 of 42

2.12

1.49

0.0014

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