Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
UBE2E2Ubiquitin conjugating enzyme E2 E2; Belongs to the ubiquitin-conjugating enzyme family. (201 aa)    
Predicted Functional Partners:
UBE2V1
Ubiquitin conjugating enzyme E2 V1.
   
 0.905
UBE2E3
Ubiquitin conjugating enzyme E2 E3; Belongs to the ubiquitin-conjugating enzyme family.
  
  
 
0.900
TRIP12
Thyroid hormone receptor interactor 12.
   
 0.895
GCDH
Glutaryl-CoA dehydrogenase.
 
 
  0.811
BIRC6
Baculoviral IAP repeat containing 6.
   
 0.743
RPS27A
Ubiquitin-like domain-containing protein.
   
 0.733
ENSAPLP00000025536
Ubiquitin-like domain-containing protein.
   
 0.711
OTUB1
OTU deubiquitinase, ubiquitin aldehyde binding 1.
   
 0.711
PRKN
Parkin RBR E3 ubiquitin protein ligase.
    
 0.694
RNF8
E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...]
   
 0.687
Your Current Organism:
Anas platyrhynchos
NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard
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