FBN2 protein (Anas platyrhynchos) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

FBN2

Fibrillin 2. (2896 aa)

Predicted Functional Partners:

ENSAPLP00000025208

0.795

ENSAPLP00000020792

0.753

FBN1

0.701

FURIN

0.633

HMMR

0.590

ADAMTS3

0.587

MFAP5

0.570

FRAS1

0.550

NOS2

0.549

LUM

0.541

Your Current Organism:

Anas platyrhynchos

NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADAMTS3	FBN2	ENSAPLP00000010086	ENSAPLP00000005262	ADAM metallopeptidase with thrombospondin type 1 motif 3.	Fibrillin 2.	0.587
ADAMTS3	NOS2	ENSAPLP00000010086	ENSAPLP00000016156	ADAM metallopeptidase with thrombospondin type 1 motif 3.	Nitric oxide synthase; Produces nitric oxide (NO).	0.536
ENSAPLP00000020792	FBN1	ENSAPLP00000020792	ENSAPLP00000005379	NTR domain-containing protein.	Fibrillin 1.	0.659
ENSAPLP00000020792	FBN2	ENSAPLP00000020792	ENSAPLP00000005262	NTR domain-containing protein.	Fibrillin 2.	0.753
ENSAPLP00000025208	FBN1	ENSAPLP00000025208	ENSAPLP00000005379	Uncharacterized protein.	Fibrillin 1.	0.894
ENSAPLP00000025208	FBN2	ENSAPLP00000025208	ENSAPLP00000005262	Uncharacterized protein.	Fibrillin 2.	0.795
ENSAPLP00000025208	MFAP5	ENSAPLP00000025208	ENSAPLP00000013815	Uncharacterized protein.	Microfibril associated protein 5.	0.718
FBN1	ENSAPLP00000020792	ENSAPLP00000005379	ENSAPLP00000020792	Fibrillin 1.	NTR domain-containing protein.	0.659
FBN1	ENSAPLP00000025208	ENSAPLP00000005379	ENSAPLP00000025208	Fibrillin 1.	Uncharacterized protein.	0.894
FBN1	FBN2	ENSAPLP00000005379	ENSAPLP00000005262	Fibrillin 1.	Fibrillin 2.	0.701
FBN1	FURIN	ENSAPLP00000005379	ENSAPLP00000005567	Fibrillin 1.	Furin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family.	0.654
FBN1	LUM	ENSAPLP00000005379	ENSAPLP00000021375	Fibrillin 1.	Lumican.	0.939
FBN1	MFAP5	ENSAPLP00000005379	ENSAPLP00000013815	Fibrillin 1.	Microfibril associated protein 5.	0.769
FBN2	ADAMTS3	ENSAPLP00000005262	ENSAPLP00000010086	Fibrillin 2.	ADAM metallopeptidase with thrombospondin type 1 motif 3.	0.587
FBN2	ENSAPLP00000020792	ENSAPLP00000005262	ENSAPLP00000020792	Fibrillin 2.	NTR domain-containing protein.	0.753
FBN2	ENSAPLP00000025208	ENSAPLP00000005262	ENSAPLP00000025208	Fibrillin 2.	Uncharacterized protein.	0.795
FBN2	FBN1	ENSAPLP00000005262	ENSAPLP00000005379	Fibrillin 2.	Fibrillin 1.	0.701
FBN2	FRAS1	ENSAPLP00000005262	ENSAPLP00000002405	Fibrillin 2.	Uncharacterized protein.	0.550
FBN2	FURIN	ENSAPLP00000005262	ENSAPLP00000005567	Fibrillin 2.	Furin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family.	0.633
FBN2	HMMR	ENSAPLP00000005262	ENSAPLP00000018047	Fibrillin 2.	Hyaluronan mediated motility receptor.	0.590

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

24

average node degree:

4.36

avg. local clustering coefficient:

0.903

expected number of edges:

10

PPI enrichment p-value:

0.000173

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006260

DNA replication

8 of 46

1.55

2.55

1.08e-08

GO:0006259

DNA metabolic process

9 of 117

1.19

1.57

1.10e-07

GO:0006261

DNA-templated DNA replication

3 of 16

1.58

1.09

0.0046

GO:0034654

Nucleobase-containing compound biosynthetic process

6 of 108

1.05

0.92

0.00065

GO:0006269

DNA replication, synthesis of RNA primer

2 of 5

1.91

0.87

0.0220

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003887

DNA-directed DNA polymerase activity

4 of 14

1.76

1.71

0.00019

GO:0016779

Nucleotidyltransferase activity

5 of 36

1.45

0.00019

GO:0140097

Catalytic activity, acting on DNA

6 of 66

1.26

1.25

0.00019

GO:0140640

Catalytic activity, acting on a nucleic acid

7 of 150

0.97

0.91

0.00019

GO:0003677

DNA binding

8 of 187

0.94

0.86

0.00019

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030894

Replisome

3 of 6

2.0

1.57

0.00080

GO:0061695

Transferase complex, transferring phosphorus-containing groups

3 of 9

1.83

1.5

0.00080

GO:0009360

DNA polymerase III complex

2 of 3

2.13

1.33

0.0030

GO:0140535

Intracellular protein-containing complex

3 of 15

1.61

1.28

0.0015

GO:1990077

Primosome complex

2 of 4

2.0

1.26

0.0036

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:575

DNA replication, and Bacterial nucleoid

8 of 14

2.06

5.07

5.57e-13

CL:523

Mismatch repair, and DNA damage

10 of 40

1.7

3.97

6.50e-14

CL:591

Primosome, and Bacterial nucleoid

4 of 6

2.13

2.61

5.39e-06

CL:579

DNA polymerase III subunits gamma and tau domain III, and Helix-hairpin-helix motif

3 of 5

2.08

1.77

0.00034

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03030

DNA replication

7 of 31

1.66

2.86

7.89e-09

map03430

Mismatch repair

6 of 27

1.65

2.54

1.54e-07

map03440

Homologous recombination

6 of 36

1.53

2.18

4.78e-07

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0009360

DNA polymerase III complex

3 of 4

2.18

1.87

0.00024

GOCC:0061695

Transferase complex, transferring phosphorus-containing groups

5 of 31

1.51

1.62

8.25e-05

GOCC:1990077

Primosome complex

2 of 6

1.83

0.87

0.0204

GOCC:1902494

Catalytic complex

6 of 130

0.97

0.83

0.00077

GOCC:0032991

Protein-containing complex

7 of 315

0.65

0.46

0.0093

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0235

DNA replication

6 of 15

1.91

3.25

2.46e-08

KW-0238

DNA-binding

7 of 105

1.13

1.24

1.61e-05

KW-0639

Primosome

2 of 2

2.31

1.14

0.0076

KW-0239

DNA-directed DNA polymerase

2 of 5

1.91

0.94

0.0159

KW-0548

Nucleotidyltransferase

3 of 22

1.44

0.93

0.0084

(more ...)

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR027417

P-loop containing nucleoside triphosphate hydrolase

7 of 152

0.97

0.78

0.0019

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