ICE2 protein (Anas platyrhynchos) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

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[Homology]

Score

ICE2

Interactor of little elongation complex ELL subunit 2. (850 aa)

Predicted Functional Partners:

ELL

0.837

ENSAPLP00000024913

0.694

ELL2

0.694

USPL1

0.628

EAF1

0.602

ZC3H6

0.599

ZC3H6-2

0.599

EAF2

0.592

SUPT4H1

0.558

RPAP2

0.556

Your Current Organism:

Anas platyrhynchos

NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EAF1	EAF2	ENSAPLP00000030437	ENSAPLP00000026012	ELL associated factor 1.	ELL associated factor 2.	0.965
EAF1	ELL	ENSAPLP00000030437	ENSAPLP00000005983	ELL associated factor 1.	Elongation factor for RNA polymerase II.	0.983
EAF1	ELL2	ENSAPLP00000030437	ENSAPLP00000030942	ELL associated factor 1.	Elongation factor for RNA polymerase II 2.	0.876
EAF1	ENSAPLP00000024913	ENSAPLP00000030437	ENSAPLP00000024913	ELL associated factor 1.	Uncharacterized protein.	0.876
EAF1	ICE2	ENSAPLP00000030437	ENSAPLP00000005583	ELL associated factor 1.	Interactor of little elongation complex ELL subunit 2.	0.602
EAF1	SUPT4H1	ENSAPLP00000030437	ENSAPLP00000012278	ELL associated factor 1.	Transcription elongation factor SPT4; Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates transcription elongation by RNA polymerase II; Belongs to the SPT4 family.	0.858
EAF2	EAF1	ENSAPLP00000026012	ENSAPLP00000030437	ELL associated factor 2.	ELL associated factor 1.	0.965
EAF2	ELL	ENSAPLP00000026012	ENSAPLP00000005983	ELL associated factor 2.	Elongation factor for RNA polymerase II.	0.965
EAF2	ELL2	ENSAPLP00000026012	ENSAPLP00000030942	ELL associated factor 2.	Elongation factor for RNA polymerase II 2.	0.831
EAF2	ENSAPLP00000024913	ENSAPLP00000026012	ENSAPLP00000024913	ELL associated factor 2.	Uncharacterized protein.	0.831
EAF2	ICE2	ENSAPLP00000026012	ENSAPLP00000005583	ELL associated factor 2.	Interactor of little elongation complex ELL subunit 2.	0.592
EAF2	SUPT4H1	ENSAPLP00000026012	ENSAPLP00000012278	ELL associated factor 2.	Transcription elongation factor SPT4; Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates transcription elongation by RNA polymerase II; Belongs to the SPT4 family.	0.798
ELL	EAF1	ENSAPLP00000005983	ENSAPLP00000030437	Elongation factor for RNA polymerase II.	ELL associated factor 1.	0.983
ELL	EAF2	ENSAPLP00000005983	ENSAPLP00000026012	Elongation factor for RNA polymerase II.	ELL associated factor 2.	0.965
ELL	ELL2	ENSAPLP00000005983	ENSAPLP00000030942	Elongation factor for RNA polymerase II.	Elongation factor for RNA polymerase II 2.	0.426
ELL	ICE2	ENSAPLP00000005983	ENSAPLP00000005583	Elongation factor for RNA polymerase II.	Interactor of little elongation complex ELL subunit 2.	0.837
ELL	RPAP2	ENSAPLP00000005983	ENSAPLP00000015044	Elongation factor for RNA polymerase II.	RNA polymerase II associated protein 2.	0.428
ELL	SUPT4H1	ENSAPLP00000005983	ENSAPLP00000012278	Elongation factor for RNA polymerase II.	Transcription elongation factor SPT4; Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates transcription elongation by RNA polymerase II; Belongs to the SPT4 family.	0.776
ELL	USPL1	ENSAPLP00000005983	ENSAPLP00000003484	Elongation factor for RNA polymerase II.	Ubiquitin specific peptidase like 1.	0.416
ELL	ZC3H6	ENSAPLP00000005983	ENSAPLP00000014122	Elongation factor for RNA polymerase II.	Zinc finger CCCH-type containing 6.	0.428

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

10

PPI enrichment p-value:

< 1.0e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006096

Glycolytic process

7 of 11

2.34

5.49

2.87e-12

GO:0005975

Carbohydrate metabolic process

11 of 145

1.41

2.68

5.14e-13

GO:0006091

Generation of precursor metabolites and energy

8 of 88

1.49

2.55

1.34e-09

GO:0019637

Organophosphate metabolic process

8 of 165

1.22

1.63

1.21e-07

GO:0006002

Fructose 6-phosphate metabolic process

2 of 2

2.53

1.55

0.0014

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003872

6-phosphofructokinase activity

2 of 2

2.53

0.84

0.0298

GO:0016832

Aldehyde-lyase activity

2 of 6

2.06

0.78

0.0346

GO:0016861

Intramolecular oxidoreductase activity, interconverting aldoses and ketoses

2 of 8

1.93

0.72

0.0443

GO:0046872

Metal ion binding

6 of 417

0.69

0.4

0.0443

GO:0003824

Catalytic activity

11 of 1849

0.31

0.24

0.0443

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005737

Cytoplasm

9 of 1020

0.48

0.32

0.0314

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:892

Pentose phosphate pathway, and Glycolysis / Gluconeogenesis

11 of 30

2.1

7.15

5.13e-20

CL:893

Glycolytic process, and Phosphoenolpyruvate carboxykinase activity

9 of 18

2.23

6.75

1.77e-16

CL:895

Glycolytic process, and Glyceraldehyde/Erythrose phosphate dehydrogenase family

5 of 11

2.19

3.55

4.52e-08

CL:896

Phosphofructokinase, and Aldehyde-lyase activity

3 of 6

2.23

1.94

0.00019

CL:907

Glyceraldehyde/Erythrose phosphate dehydrogenase family, and Glycolysis

2 of 5

2.13

0.94

0.0172

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

mtt00030

Pentose phosphate pathway

7 of 18

2.12

4.96

4.06e-12

mtt00051

Fructose and mannose metabolism

6 of 11

2.27

4.96

2.90e-11

mtt00010

Glycolysis / Gluconeogenesis

7 of 31

1.89

4.05

3.01e-11

mtt01200

Carbon metabolism

10 of 86

1.6

3.5

8.61e-14

mtt01230

Biosynthesis of amino acids

9 of 111

1.44

2.61

2.90e-11

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005945

6-phosphofructokinase complex

2 of 2

2.53

1.05

0.0123

GOCC:0005737

Cytoplasm

9 of 819

0.57

0.4

0.0123

GOCC:0005622

Intracellular

10 of 1182

0.46

0.34

0.0123

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0324

Glycolysis

6 of 9

2.36

4.85

1.17e-10

KW-0460

Magnesium

5 of 80

1.33

1.31

0.00022

KW-0021

Allosteric enzyme

2 of 4

2.23

1.13

0.0077

KW-0413

Isomerase

3 of 63

1.21

0.67

0.0256

KW-0963

Cytoplasm

5 of 212

0.91

0.62

0.0097

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00365

Phosphofructokinase

2 of 2

2.53

0.88

0.0248

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