Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
IRF5IRF-3 domain-containing protein. (174 aa)    
Predicted Functional Partners:
MYD88
Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.
   
 0.667
TRAF6
TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.
    
 0.656
TLR7
Toll like receptor 7; Belongs to the Toll-like receptor family.
   
 
 0.633
IL6
Uncharacterized protein.
   
 0.630
STAT4
Signal transducer and activator of transcription.
    
 0.610
BANK1
B cell scaffold protein with ankyrin repeats 1.
   
  
 0.583
IL10
Interleukin 10.
    
 
 0.576
TLR3
Toll like receptor 3; Belongs to the Toll-like receptor family.
   
 
 0.570
IRF1
Interferon regulatory factor 1.
   
 0.569
IFNG
Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.
    
 
 0.559
Your Current Organism:
Anas platyrhynchos
NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard
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