Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
AXIN1Axin 1. (841 aa)    
Predicted Functional Partners:
CTNNB1
Catenin beta 1.
    
 0.993
GSK3B
Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily.
   
 0.992
CSNK1A1
Casein kinase 1 alpha 1; Belongs to the protein kinase superfamily.
    
 0.988
DVL3
Dishevelled segment polarity protein 3.
   
 0.984
APC2
APC regulator of WNT signaling pathway 2.
   
 0.982
APC
APC regulator of WNT signaling pathway.
   
 0.982
DVL1
Dishevelled segment polarity protein 1.
   
 0.976
U3J4W3_ANAPP
Uncharacterized protein.
    
 0.957
LRP6
Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.
    
 0.932
TNKS
Poly [ADP-ribose] polymerase.
    
 0.910
Your Current Organism:
Anas platyrhynchos
NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard
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