U3IF68_ANAPP protein (Anas platyrhynchos) - STRING interaction network

Nodes:

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second shell of interactors

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filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

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Coexpression

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[Homology]

Score

U3IF68_ANAPP

Uncharacterized protein. (234 aa)

Predicted Functional Partners:

NDUFS8

0.979

NDUFS1

0.979

NDUFS3

0.979

ENSAPLP00000022825

0.979

NDUFV2

0.979

NDUFA8

0.953

NDUFB8

0.950

NDUFB9

0.948

ENSAPLP00000030867

0.948

NDUFB10

0.943

Your Current Organism:

Anas platyrhynchos

NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSAPLP00000022825	ENSAPLP00000030867	ENSAPLP00000022825	ENSAPLP00000030867	Complex1_49kDa domain-containing protein.	Uncharacterized protein.	0.992
ENSAPLP00000022825	NDUFA8	ENSAPLP00000022825	ENSAPLP00000030506	Complex1_49kDa domain-containing protein.	NADH:ubiquinone oxidoreductase subunit A8.	0.999
ENSAPLP00000022825	NDUFB10	ENSAPLP00000022825	ENSAPLP00000008102	Complex1_49kDa domain-containing protein.	NADH:ubiquinone oxidoreductase subunit B10.	0.992
ENSAPLP00000022825	NDUFB8	ENSAPLP00000022825	ENSAPLP00000015008	Complex1_49kDa domain-containing protein.	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.	0.998
ENSAPLP00000022825	NDUFB9	ENSAPLP00000022825	ENSAPLP00000006756	Complex1_49kDa domain-containing protein.	NADH:ubiquinone oxidoreductase subunit B9; Belongs to the complex I LYR family.	0.996
ENSAPLP00000022825	NDUFS1	ENSAPLP00000022825	ENSAPLP00000003819	Complex1_49kDa domain-containing protein.	NADH:ubiquinone oxidoreductase core subunit S1; Belongs to the complex I 75 kDa subunit family.	0.999
ENSAPLP00000022825	NDUFS3	ENSAPLP00000022825	ENSAPLP00000018173	Complex1_49kDa domain-containing protein.	NADH:ubiquinone oxidoreductase core subunit S3; Belongs to the complex I 30 kDa subunit family.	0.999
ENSAPLP00000022825	NDUFS8	ENSAPLP00000022825	ENSAPLP00000001172	Complex1_49kDa domain-containing protein.	4Fe-4S ferredoxin-type domain-containing protein.	0.999
ENSAPLP00000022825	NDUFV2	ENSAPLP00000022825	ENSAPLP00000032156	Complex1_49kDa domain-containing protein.	NADH:ubiquinone oxidoreductase core subunit V2.	0.999
ENSAPLP00000022825	U3IF68_ANAPP	ENSAPLP00000022825	ENSAPLP00000005890	Complex1_49kDa domain-containing protein.	Uncharacterized protein.	0.979
ENSAPLP00000030867	ENSAPLP00000022825	ENSAPLP00000030867	ENSAPLP00000022825	Uncharacterized protein.	Complex1_49kDa domain-containing protein.	0.992
ENSAPLP00000030867	NDUFA8	ENSAPLP00000030867	ENSAPLP00000030506	Uncharacterized protein.	NADH:ubiquinone oxidoreductase subunit A8.	0.999
ENSAPLP00000030867	NDUFB10	ENSAPLP00000030867	ENSAPLP00000008102	Uncharacterized protein.	NADH:ubiquinone oxidoreductase subunit B10.	0.999
ENSAPLP00000030867	NDUFB8	ENSAPLP00000030867	ENSAPLP00000015008	Uncharacterized protein.	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.	0.999
ENSAPLP00000030867	NDUFB9	ENSAPLP00000030867	ENSAPLP00000006756	Uncharacterized protein.	NADH:ubiquinone oxidoreductase subunit B9; Belongs to the complex I LYR family.	0.999
ENSAPLP00000030867	NDUFS1	ENSAPLP00000030867	ENSAPLP00000003819	Uncharacterized protein.	NADH:ubiquinone oxidoreductase core subunit S1; Belongs to the complex I 75 kDa subunit family.	0.990
ENSAPLP00000030867	NDUFS3	ENSAPLP00000030867	ENSAPLP00000018173	Uncharacterized protein.	NADH:ubiquinone oxidoreductase core subunit S3; Belongs to the complex I 30 kDa subunit family.	0.997
ENSAPLP00000030867	NDUFS8	ENSAPLP00000030867	ENSAPLP00000001172	Uncharacterized protein.	4Fe-4S ferredoxin-type domain-containing protein.	0.999
ENSAPLP00000030867	NDUFV2	ENSAPLP00000030867	ENSAPLP00000032156	Uncharacterized protein.	NADH:ubiquinone oxidoreductase core subunit V2.	0.994
ENSAPLP00000030867	U3IF68_ANAPP	ENSAPLP00000030867	ENSAPLP00000005890	Uncharacterized protein.	Uncharacterized protein.	0.948

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Network Stats

number of nodes:

11

number of edges:

27

average node degree:

4.91

avg. local clustering coefficient:

0.589

expected number of edges:

10

PPI enrichment p-value:

7.05e-06

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:2000169

Regulation of peptidyl-cysteine S-nitrosylation

4 of 8

3.02

3.79

1.16e-07

GO:0098974

Postsynaptic actin cytoskeleton organization

4 of 15

2.74

3.41

4.54e-07

GO:0060307

Regulation of ventricular cardiac muscle cell membrane repolarization

4 of 15

2.74

3.41

4.54e-07

GO:1901385

Regulation of voltage-gated calcium channel activity

4 of 39

2.33

2.78

4.11e-06

GO:0002027

Regulation of heart rate

4 of 40

2.32

2.77

4.11e-06

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0050998

Nitric-oxide synthase binding

4 of 8

3.02

4.04

3.84e-08

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016010

Dystrophin-associated glycoprotein complex

4 of 14

2.77

3.74

1.11e-07

GO:0002102

Podosome

4 of 18

2.66

3.66

1.33e-07

GO:0033017

Sarcoplasmic reticulum membrane

4 of 31

2.43

3.28

4.74e-07

GO:0030175

Filopodium

4 of 72

2.06

2.57

5.11e-06

GO:0030018

Z disc

4 of 102

1.91

2.24

1.61e-05

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:36908

Mixed, incl. Dystrophin-associated glycoprotein complex, and EF hand

7 of 31

2.67

6.88

3.20e-14

CL:36910

EF hand, and Syntrophin

4 of 12

2.84

3.88

6.57e-08

CL:36947

Mixed, incl. Torsin 1/2, and Torsin-1A-interacting protein 1/2

3 of 10

2.79

2.56

1.97e-05

CL:36950

Nitric-oxide synthase binding, and Torsin 1/2

2 of 5

2.92

1.39

0.0031

CL:36912

Mixed, incl. EF hand, and Syntrophin, split Pleckstrin homology (PH) domain

2 of 7

2.77

1.28

0.0047

Tissue Expression (TISSUES)

tissue

description

count in network

strength

signal

false discovery rate

BTO:0000562

Heart

4 of 407

1.31

1.26

0.00028

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0016010

Dystrophin-associated glycoprotein complex

5 of 24

2.64

4.6

1.60e-09

GOCC:0045202

Synapse

4 of 531

1.19

0.68

0.0232

GOCC:0016020

Membrane

9 of 5135

0.56

0.38

0.0197

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR015482

Syntrophin

4 of 4

3.32

4.32

1.44e-08

IPR041428

Syntrophin, split Pleckstrin homology (PH) domain

3 of 3

3.32

2.98

4.04e-06

IPR011993

PH-like domain superfamily

7 of 529

1.44

1.83

4.04e-06

IPR006020

PTB/PI domain

3 of 57

2.04

1.28

0.0035

IPR001478

PDZ domain

4 of 201

1.62

1.15

0.0035

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00462

Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain

3 of 39

2.2

1.64

0.00073

SM00233

Pleckstrin homology domain.

4 of 325

1.41

0.99

0.0050

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