CBR4 protein (Anas platyrhynchos) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

CBR4

Carbonyl reductase 4. (237 aa)

Predicted Functional Partners:

OXSM

0.981

FASN

0.934

MCAT

0.820

VWA8

0.779

PAX2

0.768

RTN4IP1

0.679

CYP19A1

0.633

ENSAPLP00000030867

0.593

SNX10

0.555

AGMO

0.532

Your Current Organism:

Anas platyrhynchos

NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGMO	CBR4	ENSAPLP00000023352	ENSAPLP00000006269	Alkylglycerol monooxygenase; Belongs to the sterol desaturase family.	Carbonyl reductase 4.	0.532
CBR4	AGMO	ENSAPLP00000006269	ENSAPLP00000023352	Carbonyl reductase 4.	Alkylglycerol monooxygenase; Belongs to the sterol desaturase family.	0.532
CBR4	CYP19A1	ENSAPLP00000006269	ENSAPLP00000007334	Carbonyl reductase 4.	Cytochrome P450 family 19 subfamily A member 1; Belongs to the cytochrome P450 family.	0.633
CBR4	ENSAPLP00000030867	ENSAPLP00000006269	ENSAPLP00000030867	Carbonyl reductase 4.	Uncharacterized protein.	0.593
CBR4	FASN	ENSAPLP00000006269	ENSAPLP00000002286	Carbonyl reductase 4.	Fatty acid synthase.	0.934
CBR4	MCAT	ENSAPLP00000006269	ENSAPLP00000016990	Carbonyl reductase 4.	Malonyl-CoA-acyl carrier protein transacylase.	0.820
CBR4	OXSM	ENSAPLP00000006269	ENSAPLP00000007697	Carbonyl reductase 4.	3-oxoacyl-[acyl-carrier-protein] synthase; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.	0.981
CBR4	PAX2	ENSAPLP00000006269	ENSAPLP00000014485	Carbonyl reductase 4.	Paired box 2.	0.768
CBR4	RTN4IP1	ENSAPLP00000006269	ENSAPLP00000008859	Carbonyl reductase 4.	Reticulon 4 interacting protein 1.	0.679
CBR4	SNX10	ENSAPLP00000006269	ENSAPLP00000031785	Carbonyl reductase 4.	Sorting nexin 10.	0.555
CBR4	VWA8	ENSAPLP00000006269	ENSAPLP00000010547	Carbonyl reductase 4.	Von Willebrand factor A domain containing 8.	0.779
CYP19A1	CBR4	ENSAPLP00000007334	ENSAPLP00000006269	Cytochrome P450 family 19 subfamily A member 1; Belongs to the cytochrome P450 family.	Carbonyl reductase 4.	0.633
CYP19A1	FASN	ENSAPLP00000007334	ENSAPLP00000002286	Cytochrome P450 family 19 subfamily A member 1; Belongs to the cytochrome P450 family.	Fatty acid synthase.	0.415
CYP19A1	PAX2	ENSAPLP00000007334	ENSAPLP00000014485	Cytochrome P450 family 19 subfamily A member 1; Belongs to the cytochrome P450 family.	Paired box 2.	0.688
ENSAPLP00000030867	CBR4	ENSAPLP00000030867	ENSAPLP00000006269	Uncharacterized protein.	Carbonyl reductase 4.	0.593
ENSAPLP00000030867	RTN4IP1	ENSAPLP00000030867	ENSAPLP00000008859	Uncharacterized protein.	Reticulon 4 interacting protein 1.	0.464
ENSAPLP00000030867	VWA8	ENSAPLP00000030867	ENSAPLP00000010547	Uncharacterized protein.	Von Willebrand factor A domain containing 8.	0.735
FASN	CBR4	ENSAPLP00000002286	ENSAPLP00000006269	Fatty acid synthase.	Carbonyl reductase 4.	0.934
FASN	CYP19A1	ENSAPLP00000002286	ENSAPLP00000007334	Fatty acid synthase.	Cytochrome P450 family 19 subfamily A member 1; Belongs to the cytochrome P450 family.	0.415
FASN	MCAT	ENSAPLP00000002286	ENSAPLP00000016990	Fatty acid synthase.	Malonyl-CoA-acyl carrier protein transacylase.	0.969

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

33

average node degree:

6

avg. local clustering coefficient:

0.936

expected number of edges:

12

PPI enrichment p-value:

2.2e-07

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0072318

Clathrin coat disassembly

3 of 8

2.82

2.23

8.39e-05

GO:0007175

Negative regulation of epidermal growth factor-activated receptor activity

3 of 11

2.68

2.21

8.39e-05

GO:0048488

Synaptic vesicle endocytosis

4 of 40

2.24

2.11

8.39e-05

GO:0061097

Regulation of protein tyrosine kinase activity

4 of 73

1.98

1.97

9.58e-05

GO:0001933

Negative regulation of protein phosphorylation

5 of 225

1.59

1.66

0.00011

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0047690

Aspartyltransferase activity

3 of 3

3.24

2.81

8.25e-06

GO:0001784

Phosphotyrosine residue binding

4 of 45

2.19

2.41

1.79e-05

GO:0017124

SH3 domain binding

4 of 84

1.92

1.98

7.77e-05

GO:0030971

Receptor tyrosine kinase binding

3 of 66

1.9

1.35

0.0021

GO:0019900

Kinase binding

6 of 583

1.26

1.27

0.00014

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0045121

Membrane raft

5 of 192

1.66

1.79

7.07e-05

GO:0098793

Presynapse

5 of 347

1.4

1.31

0.00042

GO:0030054

Cell junction

7 of 1473

0.92

0.75

0.0015

GO:0098978

Glutamatergic synapse

3 of 206

1.41

0.73

0.0270

GO:0031982

Vesicle

7 of 1679

0.86

0.67

0.0028

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:14675

Mixed, incl. Adaptor protein Cbl, and Sprouty

5 of 12

2.86

4.96

5.50e-10

CL:14678

Synaptic vesicle uncoating, and Adaptor protein Cbl

4 of 6

3.07

4.15

2.58e-08

CL:14423

PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, and Transmembrane receptor protein tyrosine kinase signaling pathway

6 of 138

1.88

3.01

9.96e-08

CL:20137

Mixed, incl. Clathrin-coated pit, and ENTH domain

3 of 50

2.02

1.33

0.0027

CL:20227

Repeat in HS1/Cortactin, and Dynamin GTPase effector domain

2 of 5

2.85

1.3

0.0045

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

oro04144

Endocytosis

8 of 243

1.76

3.66

3.81e-11

oro04012

ErbB signaling pathway

4 of 83

1.93

2.22

2.04e-05

oro04072

Phospholipase D signaling pathway

4 of 150

1.67

1.69

0.00014

oro04120

Ubiquitin mediated proteolysis

4 of 158

1.65

1.68

0.00014

oro05100

Bacterial invasion of epithelial cells

3 of 76

1.84

1.53

0.00070

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-8856828

Clathrin-mediated endocytosis

7 of 188

1.82

3.27

5.16e-09

MAP-437239

Recycling pathway of L1

4 of 25

2.45

3.1

1.14e-06

MAP-182971

EGFR downregulation

4 of 35

2.3

2.86

2.62e-06

MAP-373760

L1CAM interactions

4 of 62

2.05

2.34

1.71e-05

MAP-177929

Signaling by EGFR

4 of 63

2.05

2.33

1.71e-05

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02761

CBL proto-oncogene N-terminus, EF hand-like domain

3 of 3

3.24

2.88

6.29e-06

PF02262

CBL proto-oncogene N-terminal domain 1

3 of 3

3.24

2.88

6.29e-06

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036537

Adaptor protein Cbl, N-terminal domain superfamily

3 of 3

3.24

2.64

1.67e-05

IPR024162

Adaptor protein Cbl

3 of 3

3.24

2.64

1.67e-05

IPR024159

Adaptor protein Cbl, PTB domain

3 of 3

3.24

2.64

1.67e-05

IPR014742

Adaptor protein Cbl, SH2-like domain

3 of 3

3.24

2.64

1.67e-05

IPR014741

Adaptor protein Cbl, EF hand-like

3 of 3

3.24

2.64

1.67e-05

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00302

Dynamin GTPase effector domain

2 of 6

2.77

1.2

0.0067

SM00053

Dynamin, GTPase

2 of 7

2.7

1.2

0.0067

SM00721

BAR

2 of 13

2.43

1.13

0.0083

SM00165

Ubiquitin associated domain

2 of 32

2.04

0.79

0.0332

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (26%) [HD]

Permalink

Network

Neighborhood

Experiments

Fusion

Databases

Cooccurrence

Textmining

Coexpression

© STRING Consortium 2025

Credits

Access

Info

About