Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-occurrence
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[Homology]
Score
SH3GLB2SH3 domain containing GRB2 like, endophilin B2. (388 aa)    
Predicted Functional Partners:
SH3GLB1
SH3 domain containing GRB2 like, endophilin B1.
   
   0.947
CBLB
Cbl proto-oncogene B.
    
  0.810
CBL
Cbl proto-oncogene.
    
  0.810
PHKB
Phosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. Belongs to the phosphorylase b kinase regulatory chain family.
      
 0.668
IGF1R
Tyrosine-protein kinase receptor.
    
  0.654
EGFR
Receptor protein-tyrosine kinase.
     
  0.650
PDGFRA
Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development.
     
  0.650
VPS26C
VPS26 endosomal protein sorting factor C.
    
 
 0.650
FGFR4
Fibroblast growth factor receptor.
     
  0.650
FGFR2
Fibroblast growth factor receptor.
     
  0.650
Your Current Organism:
Anas platyrhynchos
NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard
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