Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
INPP5EInositol polyphosphate-5-phosphatase E. (639 aa)    
Predicted Functional Partners:
PDE6D
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta; Promotes the release of prenylated target proteins from cellular membranes. Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location. Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E. Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI). Increases the affinity of ARL3 for GTP by several orders of magnitude. Stabilizes ARL3-GTP by decreasing the nucleotide [...]
    
 0.992
ARL13B
ADP ribosylation factor like GTPase 13B.
     
 0.975
SACM1L
SAC1 like phosphatidylinositide phosphatase.
 
  
 0.962
PIP5K1B
Phosphatidylinositol-4-phosphate 5-kinase type 1 beta.
     
 0.952
U3IWK3_ANAPP
Uncharacterized protein.
 
  
 0.926
SYNJ2
Synaptojanin 2.
    
0.922
PIP5K1C
Phosphatidylinositol-4-phosphate 5-kinase type 1 gamma.
     
 0.919
PIP5K1A
Phosphatidylinositol-4-phosphate 5-kinase type 1 alpha.
     
 0.919
PIK3C2G
Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma; Belongs to the PI3/PI4-kinase family.
     
 0.917
PIK3C2A
Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha; Belongs to the PI3/PI4-kinase family.
     
 0.917
Your Current Organism:
Anas platyrhynchos
NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard
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