Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
USP45Ubiquitin carboxyl-terminal hydrolase. (749 aa)    
Predicted Functional Partners:
USP16
Ubiquitin carboxyl-terminal hydrolase 16; Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B.
  
  
 
0.904
ERCC1
ERCC excision repair 1, endonuclease non-catalytic subunit.
    
 0.755
ENSAPLP00000023897
Uncharacterized protein.
    
 0.720
PNISR
PNN interacting serine and arginine rich protein.
 
 
  
 0.676
OTUB1
OTU deubiquitinase, ubiquitin aldehyde binding 1.
      
 0.667
OTUD6B
OTU domain containing 6B.
      
 0.642
MIPOL1
Mirror-image polydactyly 1.
      
 0.592
KLHL7
Kelch like family member 7.
      
 0.589
CLSPN
Claspin.
      
 0.582
FAXC
Failed axon connections homolog, metaxin like GST domain containing.
      
 0.577
Your Current Organism:
Anas platyrhynchos
NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard
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