Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
AGRPAgouti domain-containing protein. (130 aa)    
Predicted Functional Partners:
MC4R
Melanocortin 4 receptor.
    
 0.995
MC3R
Melanocortin 3 receptor.
    
 0.984
POMC
Proopiomelanocortin.
      
 0.892
NPY
Neuropeptide Y.
      
 0.879
CCK
Cholecystokinin.
      
 0.832
GHRL
Ghrelin and obestatin prepropeptide.
   
  
 0.826
LEPR
Leptin receptor.
    
 
 0.735
INS
Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
   
  
 0.668
MC5R
Melanocortin 5 receptor.
    
 
 0.665
ASIP
Agouti signaling protein.
      
 0.657
Your Current Organism:
Anas platyrhynchos
NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard
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