SPTBN1 protein (Anas platyrhynchos) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

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[Homology]

Score

SPTBN1

Spectrin beta chain; Belongs to the spectrin family. (2083 aa)

Predicted Functional Partners:

SPTAN1

0.851

WDR76

0.699

RAPGEF5

0.678

RIMS2

0.678

COPS7B

0.678

CAMTA1

0.678

BARHL2

0.670

ENSAPLP00000023732

0.667

FGD5

0.655

ENSAPLP00000020757

0.572

Your Current Organism:

Anas platyrhynchos

NCBI taxonomy Id: 8840
Other names: A. platyrhynchos platyrhynchos, Anas platyrhynchos platyrhynchos, common mallard, northern mallard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BARHL2	CAMTA1	ENSAPLP00000017715	ENSAPLP00000030632	BarH like homeobox 2.	Calmodulin binding transcription activator 1.	0.673
BARHL2	COPS7B	ENSAPLP00000017715	ENSAPLP00000026832	BarH like homeobox 2.	COP9 signalosome subunit 7B.	0.670
BARHL2	FGD5	ENSAPLP00000017715	ENSAPLP00000007608	BarH like homeobox 2.	FYVE, RhoGEF and PH domain containing 5.	0.634
BARHL2	RAPGEF5	ENSAPLP00000017715	ENSAPLP00000011003	BarH like homeobox 2.	Rap guanine nucleotide exchange factor 5.	0.670
BARHL2	RIMS2	ENSAPLP00000017715	ENSAPLP00000019733	BarH like homeobox 2.	C2 domain-containing protein.	0.670
BARHL2	SPTBN1	ENSAPLP00000017715	ENSAPLP00000007172	BarH like homeobox 2.	Spectrin beta chain; Belongs to the spectrin family.	0.670
BARHL2	WDR76	ENSAPLP00000017715	ENSAPLP00000006731	BarH like homeobox 2.	WD repeat-containing protein 76; Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC. Belongs to the WD repeat DDB2/WDR76 family.	0.670
CAMTA1	BARHL2	ENSAPLP00000030632	ENSAPLP00000017715	Calmodulin binding transcription activator 1.	BarH like homeobox 2.	0.673
CAMTA1	COPS7B	ENSAPLP00000030632	ENSAPLP00000026832	Calmodulin binding transcription activator 1.	COP9 signalosome subunit 7B.	0.678
CAMTA1	FGD5	ENSAPLP00000030632	ENSAPLP00000007608	Calmodulin binding transcription activator 1.	FYVE, RhoGEF and PH domain containing 5.	0.655
CAMTA1	RAPGEF5	ENSAPLP00000030632	ENSAPLP00000011003	Calmodulin binding transcription activator 1.	Rap guanine nucleotide exchange factor 5.	0.678
CAMTA1	RIMS2	ENSAPLP00000030632	ENSAPLP00000019733	Calmodulin binding transcription activator 1.	C2 domain-containing protein.	0.684
CAMTA1	SPTBN1	ENSAPLP00000030632	ENSAPLP00000007172	Calmodulin binding transcription activator 1.	Spectrin beta chain; Belongs to the spectrin family.	0.678
CAMTA1	WDR76	ENSAPLP00000030632	ENSAPLP00000006731	Calmodulin binding transcription activator 1.	WD repeat-containing protein 76; Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC. Belongs to the WD repeat DDB2/WDR76 family.	0.678
COPS7B	BARHL2	ENSAPLP00000026832	ENSAPLP00000017715	COP9 signalosome subunit 7B.	BarH like homeobox 2.	0.670
COPS7B	CAMTA1	ENSAPLP00000026832	ENSAPLP00000030632	COP9 signalosome subunit 7B.	Calmodulin binding transcription activator 1.	0.678
COPS7B	FGD5	ENSAPLP00000026832	ENSAPLP00000007608	COP9 signalosome subunit 7B.	FYVE, RhoGEF and PH domain containing 5.	0.655
COPS7B	RAPGEF5	ENSAPLP00000026832	ENSAPLP00000011003	COP9 signalosome subunit 7B.	Rap guanine nucleotide exchange factor 5.	0.678
COPS7B	RIMS2	ENSAPLP00000026832	ENSAPLP00000019733	COP9 signalosome subunit 7B.	C2 domain-containing protein.	0.678
COPS7B	SPTBN1	ENSAPLP00000026832	ENSAPLP00000007172	COP9 signalosome subunit 7B.	Spectrin beta chain; Belongs to the spectrin family.	0.678

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

30

average node degree:

5.45

avg. local clustering coefficient:

0.949

expected number of edges:

10

PPI enrichment p-value:

6.12e-07

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0098930

Axonal transport

5 of 32

2.37

3.67

5.68e-08

GO:0047497

Mitochondrion transport along microtubule

4 of 12

2.7

3.6

1.89e-07

GO:0006607

NLS-bearing protein import into nucleus

4 of 16

2.58

3.41

3.47e-07

GO:0010970

Transport along microtubule

6 of 110

1.92

3.05

1.03e-07

GO:0000413

Protein peptidyl-prolyl isomerization

4 of 29

2.32

2.87

2.53e-06

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0061665

SUMO ligase activity

4 of 13

2.67

3.31

6.55e-07

GO:0008574

Plus-end-directed microtubule motor activity

2 of 11

2.44

1.02

0.0137

GO:0031267

Small GTPase binding

4 of 230

1.42

0.89

0.0104

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0044614

Nuclear pore cytoplasmic filaments

4 of 6

3.0

4.11

2.87e-08

GO:0005642

Annulate lamellae

4 of 7

2.94

4.09

2.87e-08

GO:0106068

SUMO ligase complex

4 of 11

2.74

3.97

3.74e-08

GO:0042405

Nuclear inclusion body

4 of 11

2.74

3.97

3.74e-08

GO:0044615

Nuclear pore nuclear basket

4 of 13

2.67

3.89

4.65e-08

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:15666

Establishment of mitochondrion localization, and CH-like domain in sperm protein

3 of 11

2.61

1.92

0.00029

CL:5958

Transport of Mature mRNA Derived from an Intronless Transcript

3 of 29

2.19

1.58

0.00098

CL:16207

RHO GTPases activate KTN1

2 of 5

2.78

1.33

0.0039

CL:15669

MIRO domain, and HAP1, N-terminal

2 of 5

2.78

1.33

0.0039

CL:5999

Mixed, incl. Nuclear pore central transport channel, and Nuclear pore cytoplasmic filaments

2 of 7

2.64

1.25

0.0052

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-3301854

Nuclear Pore Complex (NPC) Disassembly

4 of 41

2.17

2.56

7.94e-06

MAP-159231

Transport of Mature mRNA Derived from an Intronless Transcript

4 of 40

2.18

2.56

7.94e-06

MAP-159227

Transport of the SLBP independent Mature mRNA

4 of 41

2.17

2.56

7.94e-06

MAP-159234

Transport of Mature mRNAs Derived from Intronless Transcripts

4 of 44

2.14

2.54

7.94e-06

MAP-159230

Transport of the SLBP Dependant Mature mRNA

4 of 43

2.15

2.54

7.94e-06

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0044614

Nuclear pore cytoplasmic filaments

4 of 5

3.08

4.21

2.01e-08

GOCC:0031967

Organelle envelope

6 of 427

1.33

1.42

6.42e-05

GOCC:0043229

Intracellular organelle

11 of 6905

0.38

0.29

0.0165

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00160

Ran-binding domain

2 of 8

2.58

1.04

0.0130

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